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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 50 - 54 (5page)
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초록· 키워드
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Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway.
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참고문헌 (23)
참고문헌 신청
Egan, D.F. / 2011 / Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy / Science 331:456~461
Goginashvili, A. / 2015 / Insulin granules. Insulin secretory granules control autophagy in pancreatic ${\beta}$ cells / Science 347:878~882
Honda, S. / 2014 / Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes / Nat. Commun. 5:4004
Itakura, E. / 2012 / The hairpintype tail-anchored SNARE Syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes / Cell 151:1256~1269
Kaushik, S. / 2012 / Chaperone-mediated autophagy: a unique way to enter the lysosome world / Trends Cell Biol 22:407~417
Goginashvili, A. / 2015 / Insulin granules. Insulin secretory granules control autophagy in pancreatic
Honda, S. / 2014 / Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes / Nat. Commun. 5:4004
Itakura, E. / 2012 / The hairpintype tail-anchored SNARE Syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes / Cell 151:1256~1269
Kaushik, S. / 2012 / Chaperone-mediated autophagy: a unique way to enter the lysosome world / Trends Cell Biol 22:407~417
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