지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 643 - 654 (12page)
- DOI
- 10.14348/molcells.2017.0030
이용수
초록· 키워드
오류제보하기
Autophagy is a degradation pathway in eukaryotic cells in which aging proteins and organelles are sequestered into double-membrane vesicles, termed autophagosomes, which fuse with vacuoles to hydrolyze cargo. The key step in autophagy is the formation of autophagosomes, which requires different kinds of vesicles, including COPII vesicles and Atg9-containing vesicles, to transport lipid double-membranes to the phagophore assembly site (PAS). In yeast, the cis-Golgi localized t-SNARE protein Sed5 plays a role in endoplasmic reticulum (ER)-Golgi and intra-Golgi vesicular transport. We report that during autophagy, sed5-1 mutant cells could not properly transport Atg8 to the PAS, resulting in multiple Atg8 dots being dispersed into the cytoplasm. Some dots were trapped in the Golgi apparatus. Sed5 regulates the anterograde trafficking of Atg9-containing vesicles to the PAS by participating in the localization of Atg23 and Atg27 to the Golgi apparatus. Furthermore, we found that overexpression of SFT1 or SFT2 (suppressor of sed5 ts) rescued the autophagy defects in sed5-1 mutant cells. Our data suggest that Sed5 plays a novel role in autophagy, by regulating the for-mation of Atg9-containing vesicles in the Golgi apparatus, and the genetic interaction between Sft1/2 and Sed5 is essential for autophagy.
목차
등록된 정보가 없습니다.
참고문헌 (67)
참고문헌 신청
Baba, M. / 1997 / Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome / J. Cell Biol 139:1687~1695
Backues, S. K. / 2015 / Atg23 and Atg27 act at the early stages of Atg9 trafficking in S. cerevisiae / Traffic 16:172~190
Banfield, D. K. / 1995 / A SNARE-like protein required for traffic through the Golgi complex / Nature 375:806~809
Barlowe, C. / 1994 / COPII, a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum / Cell 77:895~907
Cai, H. / 2007 / TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 / Nature 445:941~944
Backues, S. K. / 2015 / Atg23 and Atg27 act at the early stages of Atg9 trafficking in S. cerevisiae / Traffic 16:172~190
Banfield, D. K. / 1995 / A SNARE-like protein required for traffic through the Golgi complex / Nature 375:806~809
Barlowe, C. / 1994 / COPII, a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum / Cell 77:895~907
Cai, H. / 2007 / TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 / Nature 445:941~944
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