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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 18 - 26 (9page)
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초록· 키워드
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Mitochondrial quality control systems are essential for the maintenance of functional mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and fission, to compensate for mitochondrial function, and mitophagy, for degrading damaged mitochondria. Specifically, in mitoph-agy, the target mitochondria are recognized by the autophagosomes and delivered to the lysosome for degradation. In this review, we describe the mechanisms of mitophagy and the factors that play an important role in this process. In particular, we focus on the roles of mitophagy adapters and receptors in the recognition of damaged mitochondria by au-tophagosomes. In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins.
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참고문헌 (84)
참고문헌 신청
Anton, Z. / 2016 / Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP / Autophagy 12:2386~2403
Ashrafi, G. / 2014 / Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin / J. Cell Biol. 206:655~670
Ban, T. / 2017 / Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin / Nat. Cell Biol. 19:856~863
Bhujabal, Z. / 2017 / FKBP8 recruits LC3A to mediate Parkin-independent mitophagy / EMBO Rep. 18:947~961
Bingol, B. / 2014 / The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy / Nature 510:370~375
Ashrafi, G. / 2014 / Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin / J. Cell Biol. 206:655~670
Ban, T. / 2017 / Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin / Nat. Cell Biol. 19:856~863
Bhujabal, Z. / 2017 / FKBP8 recruits LC3A to mediate Parkin-independent mitophagy / EMBO Rep. 18:947~961
Bingol, B. / 2014 / The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy / Nature 510:370~375
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