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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제9호
- 발행연도
- 2020.1
- 수록면
- 1,290 - 1,296 (7page)
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Recently, it was reported that entire mammalian mtDNA genomes could be transplanted into the mitochondrial networks of yeast, where they were accurately and stably maintained without rearrangement as intact genomes. Here, it was found that engineered mtDNA genomes could be readily transferred to and steadily maintained in the mitochondria of genetically modified yeast expressing the mouse mitochondrial transcription factor A (Tfam), one of the mitochondrial nucleoid proteins. The transferred mtDNA genomes were stably retained in the Tfam-expressing yeast cells for many generations. These results indicated that the engineered mouse mtDNA genomes introduced in yeast mitochondria could be relocated into the mitochondria of other cells and that the transferred genomes could be maintained within a mitochondrial environment that is highly amenable to mimicry of the biological conditions in mammalian mitochondria.
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참고문헌 (20)
참고문헌 신청
Klucnika A / 2020 / Mapping and editing animal mitochondrial genomes : can we overcome the challenges? Philos / Trans. R. Soc. Lond. B Biol. Sci 375:20190187
Yoon YG / 2019 / Intramitochondrial transfer and engineering of mammalian mitochondrial genomes in yeast / Mitochondrion 46:15~21
Larsson NG / 1998 / Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice / Nat. Genet 18:231~236
Miyakawa I / 2017 / Organization and dynamics of yeast mitochondrial nucleoids / Proc. Jpn. Acad. Ser. B Phys. Biol. Sci 93:339~359
Bonnefoy N / 2002 / Genetic transformation of Saccharomyces cerevisiae mitochondria / Methods Enzymol 350:97~111
Yoon YG / 2019 / Intramitochondrial transfer and engineering of mammalian mitochondrial genomes in yeast / Mitochondrion 46:15~21
Larsson NG / 1998 / Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice / Nat. Genet 18:231~236
Miyakawa I / 2017 / Organization and dynamics of yeast mitochondrial nucleoids / Proc. Jpn. Acad. Ser. B Phys. Biol. Sci 93:339~359
Bonnefoy N / 2002 / Genetic transformation of Saccharomyces cerevisiae mitochondria / Methods Enzymol 350:97~111
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