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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 10 - 22 (13page)
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Mitochondria have several quality control mechanisms by which they maintain cellular homeostasis and ensure that the molecular machinery is protected from stress. Mitophagy, selective autophagy of mitochondria, promotes mitochondrial quality control by inducing clearance of damaged mitochondria via the autophagic machinery. Accumulating evidence suggests that mitophagy is modulated by various microbial components in an attempt to affect the innate immune response to infection. In addition, mitophagy plays a key role in the regulation of inflammatory signaling, and mitochondrial danger signals such as mitochondrial DNA translocated into the cytosol can lead to exaggerated inflammatory responses. In this review, we present current knowledge on the functional aspects of mitophagy and its crosstalk with innate immune signaling during infection. A deeper understanding of the role of mitophagy could facilitate the development of more effective therapeutic strategies against various infections.
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참고문헌 (125)
참고문헌 신청
Amatullah, H. / 2017 / DJ-1/PARK7 impairs bacterial clearance in sepsis / Am. J. Respir. Crit. Care Med 195:889~905
Asrat, S. / 2014 / Bacterial pathogen manipulation of host membrane trafficking / Annu. Rev. Cell Dev. Biol 30:79~109
Bento, C. F. / 2015 / Autophagy in the fight against tuberculosis / DNA Cell Biol 34:228~242
Bingol, B. / 2014 / The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy / Nature 510:370~375
Burman, J. L. / 2017 / Mitochondrial fission facilitates the selective mitophagy of protein aggregates / J. Cell Biol 216:3231~3247
Asrat, S. / 2014 / Bacterial pathogen manipulation of host membrane trafficking / Annu. Rev. Cell Dev. Biol 30:79~109
Bento, C. F. / 2015 / Autophagy in the fight against tuberculosis / DNA Cell Biol 34:228~242
Bingol, B. / 2014 / The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy / Nature 510:370~375
Burman, J. L. / 2017 / Mitochondrial fission facilitates the selective mitophagy of protein aggregates / J. Cell Biol 216:3231~3247
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