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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 285 - 291 (7page)
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초록· 키워드
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Eukaryotic cells use conserved quality control mechanisms to repair or degrade defective proteins, which are synthesized at a high rate during proteotoxic stress. Quality control mechanisms include molecular chaperones, the ubiquitin-proteasome system, and autophagic machinery. Recent research reveals that during autophagy, membrane-bound organelles are selectively sequestered and degraded. Selective autophagy is also critical for the clearance of excess or damaged protein complexes (e.g., proteasomes and ribosomes) and membrane-less compartments (e.g., protein aggregates and ribonucleoprotein granules). As sessile organisms, plants rely on quality control mechanisms for their adaptation to fluctuating environments. In this mini-review, we highlight recent work elucidating the roles of selective autophagy in the quality control of proteins and RNA in plant cells. Emphasis will be placed on selective degradation of membrane-less compartments and protein complexes in the cytoplasm. We also propose possible mechanisms by which defective proteins are selectively recognized by autophagic machinery.
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참고문헌 (54)
참고문헌 신청
Balchin, D. / 2016 / In vivo aspects of protein folding and quality control / Science 353:aac4354
Broda, M. / 2018 / Mitophagy : a mechanism for plant growth and survival / Trends Plant Sci 23:434~450
Buchan, J. R. / 2013 / Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function / Cell 153:1461~1474
Chantarachot, T. / 2018 / Polysomes, stress granules, and processing bodies : a dynamic triumvirate controlling cytoplasmic mRNA fate and function / Plant Physiol 176:254~269
Cohen-Kaplan, V. / 2016 / p62-and ubiquitin-dependent stressinduced autophagy of the mammalian 26S proteasome / Proc. Natl. Acad. Sci. USA 113:E7490~E7499
Broda, M. / 2018 / Mitophagy : a mechanism for plant growth and survival / Trends Plant Sci 23:434~450
Buchan, J. R. / 2013 / Eukaryotic stress granules are cleared by autophagy and Cdc48/VCP function / Cell 153:1461~1474
Chantarachot, T. / 2018 / Polysomes, stress granules, and processing bodies : a dynamic triumvirate controlling cytoplasmic mRNA fate and function / Plant Physiol 176:254~269
Cohen-Kaplan, V. / 2016 / p62-and ubiquitin-dependent stressinduced autophagy of the mammalian 26S proteasome / Proc. Natl. Acad. Sci. USA 113:E7490~E7499
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