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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.3
- 수록면
- 195 - 201 (7page)
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초록· 키워드
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In this study, qRT-PCR was employed to identify that miR-186 expression level in NSCLC tissues are highly associated with lymph node metastasis. In addition, through the application of western blotting, luciferase assay and qRT-PCR, it was found that miR-186 targeted 3?UTR of cdc42 mRNA and down-regulated cdc42 protein level in a post-transcriptional manner. Transwell assay indicated that cdc42 partially reversed the effect of miR-186 mimics. Besides, miR-186 was proved to regulate EMT by influencing biomarkers of this process and cell adhesion ability. Thus, miR-186 is a potential target for NSCLC therapy. miR-186 is proposed to be one of tumor-suppressors and may serve as a therapeutic target in NSCLC treatment.
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참고문헌 (19)
참고문헌 신청
Bahri, S. / 2010 / The leading edge during dorsal closure as a model for epithelial plasticity : Pak is required for recruitment of the Scribble complex and septate junction formation / Development 137:2023~2032
Ben Halima, S. / 2016 / miR-186 in Alzheimers disease: a big hope for a small RNA? / J. Neurochem 137:308~311
Chou, J. / 2016 / MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42. Biochem / Biophys. Res. Commun 472:262~269
de Marinis, F. / 2008 / Clinical evidence for secondand third-line treatment options in advanced non-small cell lung cancer / Oncologist 13(Suppl 1):14~20
Etienne-Manneville, S. / 2004 / Cdc42--the centre of polarity / J. Cell Sci 117:1291~1300
Ben Halima, S. / 2016 / miR-186 in Alzheimers disease: a big hope for a small RNA? / J. Neurochem 137:308~311
Chou, J. / 2016 / MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42. Biochem / Biophys. Res. Commun 472:262~269
de Marinis, F. / 2008 / Clinical evidence for secondand third-line treatment options in advanced non-small cell lung cancer / Oncologist 13(Suppl 1):14~20
Etienne-Manneville, S. / 2004 / Cdc42--the centre of polarity / J. Cell Sci 117:1291~1300
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