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논문 기본 정보

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학술저널
저자정보
Hirai Keiji (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Ookawara Susumu (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Morino Junki (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Minato Saori (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Kaneko Shohei (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Yanai Katsunori (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Ishii Hiroki (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Matsuyama Momoko (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Kitano Taisuke (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Shindo Mitsutoshi (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Miyazawa Haruhisa (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Ito Kiyonori (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Ueda Yuichirou (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical) Watano Tatsuro (Department of Laboratory Medicine Saitama Medical Center Jichi Medical University Saitama Japan) Fujino Shinji (Department of Laboratory Medicine Saitama Medical Center Jichi Medical University Saitama Japan) Omoto Kiyoka (Department of Laboratory Medicine Saitama Medical Center Jichi Medical University Saitama Japan) Morishita Yoshiyuki (Division of Nephrology First Department of Integrated Medicine Saitama Medical Center Jichi Medical)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.39 No.4
발행연도
2020.1
수록면
441 - 450 (10page)

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Background: Few studies have investigated the relationship between serum total carbon dioxide (CO2) concentration and bicarbonate ion (HCO3 - ) concentration in patients undergoing hemodialysis. We determined the agreement and discrepancy between serum total CO2 and HCO3 - concentrations and the diagnostic accuracy of serum total CO2 for the prediction of low (HCO3 - < 24 mEq/L) and high (HCO3 - ≥ 24 mEq/L) bicarbonate concentrations in hemodialysis patients. Methods: One hundred forty-nine arteriovenous blood samples from 84 hemodialysis patients were studied. Multiple linear regression analysis was used to determine factors correlated with HCO3 - concentration. Diagnostic accuracy of serum total CO2 was evaluated using receiver operating characteristic curve analysis and a 2 × 2 table. Agreement between serum total CO2 and HCO3 - concentrations was assessed using Bland-Altman analysis. Results: Serum total CO2 concentration was closely correlated with HCO3 - concentration (β = 0.858, P < 0.001). Area under the curve of serum total CO2 for the identification of low and high bicarbonate concentrations was 0.989. Use of serum total CO2 to predict low and high bicarbonate concentrations had a sensitivity of 100%, specificity of 50.0%, positive predictive value of 96.5%, negative predictive value of 100%, and accuracy of 96.6%. Bland-Altman analysis showed moderate agreement between serum total CO2 and HCO3 - concentrations. Discrepancies between HCO3 - and serum total CO2 concentrations (serum total CO2 - HCO3 - ≤ -1) were observed in 89 samples. Conclusion: Serum total CO2 concentration is closely correlated with HCO3 - concentration in hemodialysis patients. However, there is a non-negligible discrepancy between serum total CO2 and HCO3 - concentrations.
#Acid base balance #Bicarbonate #Hemodialysis #Serum total carbon dioxide

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참고문헌 (29)

참고문헌 신청
Lefebvre A / 1989 / Optimal correction of acidosis changes progression of dialysis osteodystrophy / Kidney Int 36:1112~1118 google schola May RC / 1987 / Mechanisms for defects in muscle protein metabolism in rats with chronic uremia. Influence of metabolic acidosis / J Clin Invest 79:1099~1103 google schola Vashistha T / 2013 / Dialysis modality and correction of uremic metabolic acidosis : relationship with all-cause and causespecific mortality / Clin J Am Soc Nephrol 8:254~264 google schola Tentori F / 2013 / Association of dialysate bicarbonate concentration with mortality in the Dialysis Outcomes and Practice Patterns Study(DOPPS) / Am J Kidney Dis 62:738~746 google schola Bommer J / 2004 / Association of predialysis serum bicarbonate levels with risk of mortality and hospitalization in the Dialysis Outcomes and Practice Patterns Study(DOPPS) / Am J Kidney Dis 44:661~671 google schola

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