캠프캐럴 인근 주민에서 다이옥신류 및 유기염소계 농약의 혈중 농도 및 노출력

배상근; 김근배; 조용성; 이유미; 이덕희; 양원호; 주영수; 이관; 민영선; 임현술

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자료유형: 학술저널

저자정보: 배상근 (경북대학교병원 권역심뇌혈관질환센터) 김근배 (국립환경과학원 환경보건연구과) 조용성 (화학물질안전원 연구개발교육과) 이유미 (경북대학교 의학전문대학원 예방의학교실) 이덕희 (경북대학교 의학전문대학원 예방의학교실) 양원호 (대구가톨릭대학교 산업보건학과) 주영수 (한림대성심병원 직업환경의학과) 이관 (동국대학교 의과대학 예방의학교실) 민영선 (동국대학교 의과대학 예방의학교실) 임현술 (동국대학교 의과대학 예방의학교실)

저널정보: 한국산업보건학회 (구 한국산업위생학회) 한국산업보건학회지 한국산업보건학회지 제26권 제3호

발행연도: 2016.1

수록면: 277 - 285 (9page)

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Objectives: This study was performed in order to evaluate whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could be detected among residents living near Camp Caroll in Waegwan and whether serum concentrations of dioxins, including 2,3,7,8-TCDD, and organochlorine pesticides (OCPs) are associated with length of residence. Methods: Study subjects totaled 113 (for dioxins) and 190 (for OCPs) adults who were selected from participants in a medical investigation. Serum concentrations of dioxins and OCPs were measured using HRGC/HRMS. Information on length of residence was obtained through questionnaires. Results: 2,3,7,8-TCDD was not detected in serum among all subjects. When length of residence was classified as a categorical variable, after adjusting for confounding variables, only residents living in Waegwan for 40 years or longer tended to have high total TEQ values and 2,3,4,7,8-PeCDF with marginal significances. There was no dose-response relation between length of residence and serum concentrations of these chemicals. In multiple regression models with continuous values of the length of residence, total TEQ value and 1,2,3,4,6,7,8-HpCDF were positively associated with length of residence. However, they explained about 3-5% of total variations of serum concentrations of these compounds, while age, consumption of fatty fish, body mass index, alcohol drinking, and cigarette smoking were main variables affecting serum concentrations of dioxins or OCPs. Conclusions: In the current study, high concentrations of certain compounds were mainly observed among persons who lived in Waegwan for at least for 40 years without a dose-response relation. Therefore, it seems difficult to conclude that length of residence meaningfully contributed to the current serum concentrations of dioxins or OCPs among residents in Waegwan. However, considering the half-life of 2,3,7,8-TCDD and indirect exposure routes, the limitations of the current study design should be considered in the interpretation of the study findings.

#Dioxin #exposure #organochlorine pesticides

참고문헌 (26)

참고문헌 신청

Centers for Disease Control (CDC) / 1988 / Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in air force health study participants--preliminary report / MMWR. Morbidity and Mortality Weekly Report 37(20):309~311

Devine OJ / 1990 / Relationships between concentrations of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin serum and personal characteristics in US army Vietnam veterans / Chemosphere 20(6):681~691

Dirtu AC / 2006 / Organohalogenated pollutants in human serum from iassy, romania and their relation with age and gender / Environment International 32(6):797~803

Fromme H / 2009 / Intake and body burden of dioxin-like compounds in Germany: The INES study / Chemosphere 76(11):1457~1463

Ibarluzea J / 2011 / Sociodemographic, reproductive and dietary predictors of organochlorine compounds levels in pregnant women in Spain / Chemosphere 82(1):114~120

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