Is there any Potential Clinical Impact of Serum Phosphorus and Magnesium in Patients with Lung Cancer at First Diagnosis? A Multi-institutional Study

Kouloulias, Vassilis; Tolia, Maria; Tsoukalas, Nikolaos; Papaloucas, Christos; Pistevou-Gombaki, Kyriaki; Zygogianni, Anna; Mystakidou, Kyriaki; Kouvaris, John; Papaloucas, Marios; Psyrri, Amanda; Kyrgias, George; Gennimata, Vasiliki; Leventakos, Konstantinos; Panayiotides, Ioannis; Liakouli, Zoi; Kelekis, Nikolaos; Papaloucas, Aristofanis

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저자정보: Kouloulias, Vassilis (2nd Department of Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens) Tolia, Maria (2nd Department of Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens) Tsoukalas, Nikolaos (Medical Oncology Department, 401 Military Hospital) Papaloucas, Christos (Radiotherapy Department, AHEPA University Hospital, Medical School) Pistevou-Gombaki, Kyriaki (Radiotherapy Department, AHEPA University Hospital, Medical School) Zygogianni, Anna (1st Department of Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens) Mystakidou, Kyriaki (1st Department of Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens) Kouvaris, John (1st Department of Radiology, Radiotherapy Unit, Medical School, National Kapodistrian University of Athens) Papaloucas, Marios (Anti-doping Committee, University of Pelloponissos) Psyrri, Amanda (Medical Oncology Unit, Attikon University Hospital) Kyrgias, George (Radiotherapy Department, Larissa University Hospital) Gennimata, Vasiliki (Department of Microbiology, Medical School of Athens) Leventakos, Konstantinos (2nd Department of Pathology, Medical School of A) Panayiotides, Ioannis Liakouli, Zoi Kelekis, Nikolaos Papaloucas, Aristofanis

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제1호

발행연도: 2015.1

수록면: 77 - 81 (5page)

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Background: The aim of the study was to determine whether the expression of baseline phosphorus (P) and magnesium (Mg) levels were prognostic in terms of stage and overall survival (OS) in newly diagnosed non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) patients. Materials and Methods: Retrospectively, 130 patients were selected at the time of diagnosis oflung cancer (100 with NSCLC and 30 with SCLC), before the initialization of any chemo-radiotherapy. The median age was 67 (range 29-92). IA, IB, IIA, IIB, IIIA, IIIB and IV stages were present in 3, 4, 19, 6, 25, 8, and 65 patients, respectively. After centrifugation, the levels of serum P and Mg were measured using the nephelometric method/ photometry and evaluated before any type of treatment. Results: Higher than normal levels of P were found in 127/130 patients, while only four patients had elevated Mg serum values. In terms of Spearman test, higher P serum values correlated with either stage (rho=- 0.334, p<0.001) or OS (rho=-0.212, p=0.016). Additionally, a significant negative correlation of Mg serum levels was found with stage of disease (rho=-0.135, P=0.042). On multivariate cox-regression survival analysis, only stage (p<0.01), performance status (p<0.01) and P serum (p=0.045) showed a significant prognostic value. Conclusions: Our study indicated that pre-treatment P serum levels in lung cancer patients are higher than the normal range. Moreover, P and Mg serum levels are predictive of stage of disease. Along with stage and performance status, the P serum levels had also a significant impact on survival. This information may be important for stratifying patients to specific treatment protocols or intensifying their therapies. However, larger series are now needed to confirm our results.

#Phosphorus #Mg #serum levels #lung cancer #diagnosis #prognosis #stage #overall survival

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Kouloulias, Vassilis

소속기관 2nd Department of Radiology, Radiotherapy Unit, ATTIKON University Hospital, Medical School, Kapodis