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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: There are growing concerns about the role of vitamin D deficiency in cardiovascular diseases. Therefore, we investigated the correlation between serum 25-hydroxy-vitamin D (25[OH]D) and arterial stiffness among Korean adults. Methods: We retrospectively reviewed the medical charts of 302 people (115 women and 187 men) who visited a tertiary hospital from January 2015 to December 2016. Serum 25(OH)D was measured using the radioimmunoassay technique, and brachial-ankle pulse wave velocity (baPWV) was measured using an automatic wave analyzer. We obtained the doctor’s report on the medical history of the participants, their alcohol consumption and smoking habits, and their exercise status. Metabolic syndrome was diagnosed based on guidelines from the National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP III) and the International Diabetes Federation (IDF). Results of basic blood tests and physical assessment were also collected. Results: In the Pearson correlation analysis, serum 25(OH)D and baPWV showed a statistically significant inverse relationship (r=-0.279, P<0.001). Using multiple regression analysis, and after adjusting for possible confounders, serum 25(OH)D concentration was found to be significantly associated with baPWV (β=-0.121, P=0.011). Conclusions: We observed an association between serum 25(OH) D concentration and arterial stiffness. Further studies involving larger sample sizes will be needed to confirm this associations.
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참고문헌 (46)
참고문헌 신청
Banerjee P / 2003 / Antiproliferative role of vitamin D and its analogs--a brief overview / Mol Cell Biochem 253:247~254
Ordonez-Moran P / 2005 / Vitamin D and cancer: an update of in vitro and in vivo data / Front Biosci 10:2723~2749
Li YC / 2002 / 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system / J Clin Invest 110:229~238
Norman AW / 1980 / Vitamin D deficiency inhibits pancreatic secretion of insulin / Science 209:823~825
Hewison M / 2012 / Vitamin D and immune function: an overview / Proc Nutr Soc 71:50~61
Ordonez-Moran P / 2005 / Vitamin D and cancer: an update of in vitro and in vivo data / Front Biosci 10:2723~2749
Li YC / 2002 / 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system / J Clin Invest 110:229~238
Norman AW / 1980 / Vitamin D deficiency inhibits pancreatic secretion of insulin / Science 209:823~825
Hewison M / 2012 / Vitamin D and immune function: an overview / Proc Nutr Soc 71:50~61
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