지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 86 - 94 (9page)
이용수
초록· 키워드
오류제보하기
Background: A lineage of Klebsiella pneumoniae that produces carbapenemase-2 (KPC-2), sequence type (ST) 307, emerged in 2017. We analyzed the complete sequences of plasmids from KPC-2-producing K. pneumoniae (KPC-Kp) ST307, investigated the antimicrobial resistance conferred by this strain, and confirmed the horizontal interspecies transmission of KPC- carbapenemase-producing Enterobacteriaceae (CPE) characteristics among Enterobacteriaceae. Methods: We performed antimicrobial susceptibility testing, PCR analysis, multilocus sequence typing, curing tests, and whole-genome sequencing to characterize plasmid-derived KPC-2-producing Enterobacteriaceae clinical isolates. Results: Sequence analysis of KPC-Kp strain ST307 revealed novel plasmid-located virulence factors, including a gene cluster for glycogen synthesis. Three Enterobacteriaceae strains were identified in one patient: K. pneumoniae (CPKp1825), Klebsiella aerogenes (CPEa1826), and Escherichia coli (CPEc1827). The blaKPC-2 gene from K. pneumoniae ST307 was horizontally transmitted between these strains. The plasmids could be transferred through conjugation, because all three strains of bacteria contained the type IV secretion system, pilus genes, and tra genes for conjugal transfer. The blaKPC-2 gene was located on a truncated Tn4401 transposon. Plasmids containing the blaKPC-2 gene could not be artificially removed; thus, the three strains could not be cured. Conclusions: The ease of horizontal transfer of KPC-Kp ST307 carbapenem resistance has serious public health and epidemiological implications. This study provides a better understanding of the genetic characteristics that can contribute to the growth and spread of KPC-Kp ST307, and their association with antimicrobial resistance genes.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Eun-Jeong Yoon / 2020 / Development of Tigecycline Resistance in Carbapenemase-Producing Klebsiella pneumoniae Sequence Type 147 via AcrAB Overproduction Mediated by Replacement of the ramA Promoter / Annals of Laboratory Medicine 40(1):15~20
O’Neill J / Antimicrobial resistance: tackling a crisis for the health and wealth of nations
Pitout JD / 2015 / Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance / Antimicrob Agents Chemother 59:5873~5884
Deleo FR / 2014 / Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae / Proc Natl Acad Sci U S A 111:4988~4993
Wyres KL / 2016 / Klebsiella pneumoniae population genomics and antimicrobial-resistant clones / Trends Microbiol 24:944~956
O’Neill J / Antimicrobial resistance: tackling a crisis for the health and wealth of nations
Pitout JD / 2015 / Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance / Antimicrob Agents Chemother 59:5873~5884
Deleo FR / 2014 / Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae / Proc Natl Acad Sci U S A 111:4988~4993
Wyres KL / 2016 / Klebsiella pneumoniae population genomics and antimicrobial-resistant clones / Trends Microbiol 24:944~956
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
MCR1 and KPC2 Co-producing Klebsiella pneumoniae Bacteremia: First Case in Korea
Infection and Chemotherapy
2019 .01
-
한국형 환자분류체계의 개정연구
임상간호연구
2018 .01
-
Epidemiological Study of an Outbreak of KPC-2-producing Klebsiella pneumoniae in a Tertiary Hospital in Korea
Annals of Clinical Microbiology
2020 .01
-
Prevalence and Molecular Characteristics of Carbapenemase-Producing Enterobacteriaceae From Five Hospitals in Korea
Annals of Laboratory Medicine
2016 .01
-
최근 4년간 한 대학병원에서 분리된 Carbapenemase 생성 Enterobacteriaceae의 분자 역학과 특성 분석
Annals of Clinical Microbiology
2016 .01
-
Extensively Drug-Resistant Escherichia coli Sequence Type 1642 Carrying an IncX3 Plasmid Containing the blaKPC-2 Gene Associated with Transposon Tn4401a
Annals of Laboratory Medicine
2018 .01
-
Genetic Distribution of Carbapenem-Resistant Enterobacteriaceae in Seoul Korea, 2018~2020
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .03
-
Genotypic Distribution and Antimicrobial Susceptibilities of Carbapenemase-Producing Enterobacteriaceae Isolated From Rectal and Clinical Samples in Korean University Hospitals Between 2016 and 2019
Annals of Laboratory Medicine
2022 .01
-
Rapid Identification of OXA-48-like, KPC, NDM, and VIM Carbapenemase-Producing Enterobacteriaceae From Culture: Evaluation of the RESIST-4 O.K.N.V. Multiplex Lateral Flow Assay
Annals of Laboratory Medicine
2020 .01
-
Co-existence of VIM-2-producing Pseudomonas aeruginosa and KPC-2 and OXA-232-co-producing Klebsiella pneumoniae in the United States
Annals of Laboratory Medicine
2020 .01
-
Evolution of bla KPC Under the Pressure of Carbapenems and Ceftazidime/Avibactam in a Patient With Persistent Bacteremia Caused by Klebsiella pneumoniae
Journal of Korean Medical Science
2024 .07
-
Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals
Journal of Veterinary Science
2021 .03
-
Risk Factors for Mortality in Patients with Klebsiella pneumoniae Carbapenemase-producing K. pneumoniae and Escherichia coli bacteremia
Infection and Chemotherapy
2021 .09
-
Evaluation of Xpert Carba-R Assay v.2 to Detect Carbapenemase Genes in Two Hospitals in Korea
Annals of Laboratory Medicine
2020 .01
-
한국형 환자분류도구 (KPCS-1)의 간호시간 환산지수 산출 연구
한국간호교육학회 학술대회
2024 .07
-
Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China
Annals of Laboratory Medicine
2017 .01
-
Detection of Carbapenemases in Clinical Enterobacteriaceae Isolates Using the VITEK AST-N202 Card
Infection and Chemotherapy
2015 .01
-
Prevalence of Carbapenem-Resistant Enterobacteriaceae in Seoul, Korea
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .06
-
The Rate of Acquisition of Carbapenemase-Producing Enterobacteriaceae among Close Contact Patients Depending on Carbapenemase Enzymes
Infection and Chemotherapy
2020 .01
-
Development of a Two Triplex Real-Time Polymerase Chain Reaction for Rapid Detection of Six Carbapenemase Genes in Enterobacteriaceae
Osong Public Health and Research Persptectives
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0