지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 399 - 404 (6page)
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초록· 키워드
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Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) has been disseminating nationwide due to clonal spread and is taking a serious action at the national level in Korea. The mobilized colistin resistance (MCR1) gene confers plasmid-mediated resistance to colistin and is known to be capable of horizontal transfer between different strains of a bacterial species. We have experienced a fatal case of the patient who developed MCR1-possessing, ST307/Tn4401a[blaKPC2] K. pneumonia bacteremia in the community of non-capital region after being diagnosed as pancreatic cancer with multiple liver metastases and treated in the capital region. The ST307/Tn4401a[blaKPC2] K. pneumonia was the most commonly disseminated clone in Korea. Our strain is the first MCR1 and KPC2 co-producing K. pneumonia in Korea and our case is the critical example that the multi-drug resistant clone can cause inter-regional spread and the community-onset fatal infections. Fortunately, our patient was admitted to the intensive care unit on the day of visit, and the contact precaution was well maintained throughout and KPC-KP was not spread to other patients. The high risk patients for KPC-KP need to be screened actively, detected rapidly and preemptively isolated to prevent outbreak of KPC-KP. Inter-facility communications are essential and the nationwide epidemiologic data of KPC-KP should be analyzed and reported regularly to prevent spread of KPC-KP. The prompt identification of species and antimicrobial susceptibilities for successful treatment against KPC-KP should be emphasized as well.
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참고문헌 (20)
참고문헌 신청
Yigit H / 2001 / Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae / Antimicrob Agents Chemother 45:1151~1161
Rhee JY / 2010 / KPC-producing extreme drugresistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea / Antimicrob Agents Chemother 54:2278~2279
Park JW / 2017 / Status of carbapenemase-producing Enterobactericeae incidences in Korea, 2015-2016 / Public Health Weekly Report 10:1243~1247
Yoon EJ / 2018 / Klebsiella pneumoniae carbapenemase producers in South Korea between 2013 and 2015 / Front Microbiol 9:56
Liu YY / 2016 / Emergence of plasmid-mediated colistin resistance mechanism mcr-1 in animals and human beings in China : a microbiological and molecular biological study / Lancet Infect Dis 16:161~168
Rhee JY / 2010 / KPC-producing extreme drugresistant Klebsiella pneumoniae isolate from a patient with diabetes mellitus and chronic renal failure on hemodialysis in South Korea / Antimicrob Agents Chemother 54:2278~2279
Park JW / 2017 / Status of carbapenemase-producing Enterobactericeae incidences in Korea, 2015-2016 / Public Health Weekly Report 10:1243~1247
Yoon EJ / 2018 / Klebsiella pneumoniae carbapenemase producers in South Korea between 2013 and 2015 / Front Microbiol 9:56
Liu YY / 2016 / Emergence of plasmid-mediated colistin resistance mechanism mcr-1 in animals and human beings in China : a microbiological and molecular biological study / Lancet Infect Dis 16:161~168
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