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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 259 - 263 (5page)
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초록· 키워드
오류제보하기
There is an urgent need for accurate and rapid diagnostic assays capable of identifying carbapenemase-producing Enterobacteriaceae (CPE). We assessed the performance of the RESIST-4 O.K.N.V. (OKNV) assay (Coris BioConcept, Gembloux, Belgium) for the identification of oxacillinase (OXA)-48-like-, Klebsiella pneumoniae carbapenemase (KPC)-, New Delhi metallo-β-lactamase (NDM)-, and Verona integron-encoded metallo-β-lactamase (VIM)-producing Enterobacteriaceae grown on sheep blood agar (SBA) and the CHROMagar KPC medium. Sixty-five carbapenem-resistant Enterobacteriaceae (CRE) isolates with characterized carbapenemase content were used to evaluate the OKNV assay. The assay correctly identified all 30 isolates that produced one of the four targeted carbapenemase families. Additionally, it correctly identified 15 isolates that co-produced KPC and NDM, VIM and NDM or OXA-48-like and NDM, but failed to identify an NDM-1 and OXA-232 co-producing Klebsiella pneumoniae isolate. All 16 non-carbapenemase-producing CRE and four CPE isolates exhibited negative results, and no cross-reaction was observed. Overall, the sensitivity and specificity of the assay were 97.8% and 100%, respectively. The OKNV assay is an accurate and rapid assay for identifying OXA-48-like, KPC, NDM, and VIM carbapenemases produced by Enterobacteriaceae isolates cultured on both SBA and the CHROMagar KPC media in the clinical microbiology laboratory.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Nordmann P / 2014 / The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide / Clin Microbiol Infect 20:821~830
Patel G / 2013 / “Stormy waters ahead”: global emergence of carbapenemases / Front Microbiol 4:48
Aguirre-Quiñonero A / 2017 / Non-molecular detection of carbapenemases in Enterobacteriaceae clinical isolates / J Infect Chemother 23:1~11
Dortet L / 2012 / Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test / Antimicrob Agents Chemother 56:6437~6440
Dortet L / 2015 / Evaluation of the RAPIDEC® CARBA NP, the Rapid CARB Screen® and the Carba NP test for biochemical detection of carbapenemase-producing Enterobacteriaceae / J Antimicrob Chemother 70:3014~3022
Patel G / 2013 / “Stormy waters ahead”: global emergence of carbapenemases / Front Microbiol 4:48
Aguirre-Quiñonero A / 2017 / Non-molecular detection of carbapenemases in Enterobacteriaceae clinical isolates / J Infect Chemother 23:1~11
Dortet L / 2012 / Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test / Antimicrob Agents Chemother 56:6437~6440
Dortet L / 2015 / Evaluation of the RAPIDEC® CARBA NP, the Rapid CARB Screen® and the Carba NP test for biochemical detection of carbapenemase-producing Enterobacteriaceae / J Antimicrob Chemother 70:3014~3022
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