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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 17 - 22 (6page)
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Background: Extensively drug-resistant (XDR) Enterobacteriaceae carrying the blaKPC gene have emerged as a major global therapeutic concern. The purpose of this study was to analyze the complete sequences of plasmids from KPC-2 carbapenemase-producing XDR Escherichia coli sequence type (ST) 1642 isolates. Methods: We performed antimicrobial susceptibility testing, PCR, multilocus sequence typing (MLST), and whole-genome sequencing to characterize the plasmid-mediated KPC- 2-producing E. coli clinical isolates. Results: The isolates were resistant to most available antibiotics, including meropenem, ampicillin, ceftriaxone, gentamicin, and ciprofloxacin, but susceptible to tigecycline and colistin. The isolates were identified as the rare ST1642 by MLST. The isolates carried four plasmids: the first 69-kb conjugative IncX3 plasmid harbors blaKPC-2 within a truncated Tn4401a transposon and blaSHV-11 with duplicated conjugative elements. The second 142-kb plasmid with a multireplicon consisting of IncQ, IncFIA, and IncIB carries blaTEM-1b and two class 1 integrons. This plasmid also harbors a wide variety of additional antimicrobial resistance genes including aadA5, dfrA17, mph(A), sul1, tet(B), aac(3’)-IId, strA, strB, and sul2. Conclusions: The complete sequence analysis of plasmids from an XDR E. coli strain related to persistent infection showed the coexistence of a blaKPC-2–carrying IncX3-type plasmid and a class 1 integron-harboring multireplicon, suggesting its potential to cause outbreaks. Of additional clinical significance, the rare ST1642, identified in a cat, could constitute the source of human infection.
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참고문헌 (20)
참고문헌 신청
Lee CR / 2016 / Global dissemination of carbapenemase-producing Klebsiella pneumoniae: epidemiology, genetic Context, treatment options, and detection methods / Front Microbiol 7:895
Chen YT / 2014 / KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan / J Antimicrob Chemother 69:628~631
Adler A / 2015 / A multicenter study of the clonal structure and resistance mechanism of KPC-producing Escherichia coli isolates in Israel / Clin Microbiol Infect 21:230~235
Piazza A / 2016 / Emergence of Escherichia coli Sequence Type 131 (ST131) and ST3948 with KPC-2, KPC-3 and KPC-8 carbapenemases from a Long-Term Care and Rehabilitation Facility (LTCRF) in Northern Italy / Adv Exp Med Biol 901:77~89
Chavda KD / 2016 / Molecular diversity and plasmid analysis of KPC-producing Escherichia coli / Antimicrob Agents Chemother 60:4073~4081
Chen YT / 2014 / KPC-2-encoding plasmids from Escherichia coli and Klebsiella pneumoniae in Taiwan / J Antimicrob Chemother 69:628~631
Adler A / 2015 / A multicenter study of the clonal structure and resistance mechanism of KPC-producing Escherichia coli isolates in Israel / Clin Microbiol Infect 21:230~235
Piazza A / 2016 / Emergence of Escherichia coli Sequence Type 131 (ST131) and ST3948 with KPC-2, KPC-3 and KPC-8 carbapenemases from a Long-Term Care and Rehabilitation Facility (LTCRF) in Northern Italy / Adv Exp Med Biol 901:77~89
Chavda KD / 2016 / Molecular diversity and plasmid analysis of KPC-producing Escherichia coli / Antimicrob Agents Chemother 60:4073~4081
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