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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제25권 제1호
- 발행연도
- 2021.1
- 수록면
- 15 - 26 (12page)
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초록· 키워드
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Peptides are short chain of amino acids linked by peptide bonds. They are widely used as effective and biocompatible active ingredients in cosmetic industry. In this study, we developed novel peptide mixture and identified its anti-pigmentation effect on melanocytes and keratinocytes. Our results revealed that peptide mixture inhibited melanosome biogenesis through the regulation of microphthalmia- associated transcription factor, a key factor of melanogenesis in melanocytes. And we observed that peptide mixture inhibited melanosome uptake through the reduction of protease-activated receptor 2, a phagocytosis-related receptor in keratinocytes. Furthermore, peptide mixture activated autophagy system resulting in degradation of transferred melanosomes in keratinocytes. The anti-pigmentation effect of multi-targeting peptide mixture was assessed in a human skin equivalent model (MelanoDerm). Melanin contents in epidermal layer were significantly decreased by topical treatment of peptide mixture, suggesting that it can be applied as a novel cosmetics material having a whitening function.
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참고문헌 (48)
참고문헌 신청
Hirobe T / 2014 / Keratinocytes regulate the function of melanocytes / Dermatol Sin 32:200~204
Hachiya A / 2001 / The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation / J Invest Dermatol 116:578~586
Hirobe T / 2013 / Effects of fibroblast-derived factors on the proliferation and differentiation of human melanocytes in culture / J Dermatol Sci 71:45~57
Schauer E / 1994 / Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes / J Clin Invest 93:2258~2262
Chakraborty AK / 1996 / Production and release of proopiomelanocortin(POMC)derived peptides by human melanocytes and keratinocytes in culture : regulation by ultraviolet B / Biochim Biophys Acta 1313:130~138
Hachiya A / 2001 / The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation / J Invest Dermatol 116:578~586
Hirobe T / 2013 / Effects of fibroblast-derived factors on the proliferation and differentiation of human melanocytes in culture / J Dermatol Sci 71:45~57
Schauer E / 1994 / Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes / J Clin Invest 93:2258~2262
Chakraborty AK / 1996 / Production and release of proopiomelanocortin(POMC)derived peptides by human melanocytes and keratinocytes in culture : regulation by ultraviolet B / Biochim Biophys Acta 1313:130~138
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