The Association Between Fasting C-peptide and Gastrointestinal Symptoms of Gastroparesis in Type 2 Diabetic Patients

Yun Huang; Honghong Zhang; Minxia Zhang; Wenya Li; Jinhua Wang; Ji Hu

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자료유형: 학술저널

저자정보: Yun Huang (Department of Endocrinology The Second Affiliated Hospital of Soochow University Suzhou China) Honghong Zhang (Department of Endocrinology The Second Affiliated Hospital of Soochow University Suzhou China) Minxia Zhang (Department of Endocrinology The Second Affiliated Hospital of Soochow University Suzhou China) Wenya Li (Department of Endocrinology The Second Affiliated Hospital of Soochow University Suzhou China) Jinhua Wang (Department of Endocrinology The Second Affiliated Hospital of Soochow University Suzhou China) Ji Hu (Department of Endocrinology The Second Affiliated Hospital of Soochow University Suzhou China)

저널정보: 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.2

발행연도: 2017.1

수록면: 254 - 261 (8page)

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Background/Aims: The relationship between C-peptide levels and gastrointestinal (GI) symptoms in type 2 diabetic patients is not clear. The purpose of this study is to examine the association between fasting C-peptide and GI symptoms of gastroparesis in type 2 diabetic patients. Methods: We recruited 333 type 2 diabetic patients into the present study. All patients filled out questionnaires of gastroparesis cardinal symptom index (GCSI) to evaluate GI symptoms. Hospital anxiety and depression scale were adopted to define anxiety and depression. Patients with GCSI scores ≥ 1.9 were regarded as having symptoms of gastroparesis. Results: In our study, 71 (21.3%) type 2 diabetic patients had GCSI scores ≥ 1.9. In comparison to patients with scores < 1.9, those with scores ≥ 1.9 had significantly lower fasting c-peptide levels (1.49 ng/mL vs 1.94 ng/mL, P < 0.001), higher prevalence of depression (40.9% vs 18.3%, P < 0.001) and anxiety (28.2% vs 13.0%, P = 0.002). Multivariate logistic regression revealed that fasting C-peptide was still significantly associated with symptoms of gastroparesis (odds ratio, 0.67; 95% confidence intervals, 0.48–0.94; P = 0.021), even after adjustments for age, sex, body mass index, HbA1c, current smoking and drinking status, anxiety, and depression. Furthermore, linear regressions showed that fasting C-peptide was independently and negatively related to GCSI scores (standardized regression coefficient, −0.29; P < 0.001) in patients with at least one GI symptom. Conclusion: GI symptoms of diabetic gastroparesis affect approximately 20% of type 2 diabetes patients and are associated with lower fasting C-peptide levels independent of depression and anxiety status.

참고문헌 (27)

참고문헌 신청

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