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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 18 - 24 (7page)
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초록· 키워드
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Notable progress has been made in the therapeutic and research applications of cyclic peptides since our previous review. New drugs based on cyclic peptides are entering the market, such as plecanatide, a cyclic peptide approved by the United States Food and Drug Administration in 2017 for the treatment of chronic idiopathic constipation. In this review, we discuss recent developments in stapled peptides, prepared with the use of chemical linkers, and bicyclic/tricyclic peptides with more than two rings. These have widespread applications for clinical and research purposes: imaging, diagnostics, improvement of oral absorption, enzyme inhibition, development of receptor agonist/antagonist, and the modulation of protein-protein interaction or protein-RNA interaction. Many cyclic peptides are expected to emerge as therapeutics and biochemical tools.
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참고문헌 (52)
참고문헌 신청
Baek, S. / 2012 / Structure of the stapled p53 peptide bound to Mdm2 / J. Am. Chem. Soc 134:103~106
Beer, A. J. / 2005 / Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients / J. Nucl. Med 46:1333~1341
Bertoldo, D. / 2016 / Phage selection of peptide macrocycles against beta-catenin to interfere with Wnt signaling / ChemMedChem 11:834~839
Cai, M. / 2013 / An unusual conformation of gamma-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells / Biochemistry 52:752~764
Carelli, J. D. / 2015 / Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex / eLife 4:e10222
Beer, A. J. / 2005 / Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients / J. Nucl. Med 46:1333~1341
Bertoldo, D. / 2016 / Phage selection of peptide macrocycles against beta-catenin to interfere with Wnt signaling / ChemMedChem 11:834~839
Cai, M. / 2013 / An unusual conformation of gamma-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells / Biochemistry 52:752~764
Carelli, J. D. / 2015 / Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex / eLife 4:e10222
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