지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 57 - 70 (14page)
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초록· 키워드
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Silk peptide, the hydrolysate of silk protein derived from cocoons, has been employed as a biomedical material and is believed to be safe for human use. Silk peptide display various bioactivities, including anti-inflammatory, immune-regulatory, anti-tumor, anti-viral, and anti-bacterial. Although earlier investigations demonstrated that silk peptide stimulates macrophages and the production of pro-inflammatory cytokines, its effect on natural killer (NK) cell function has not yet been explored. In this study, we initially confirmed that silk peptide enhances NK cell activity in vitro and ex vivo. To assess the modulatory activity of silk peptide on NK cells, mice were fed various amounts of a silk peptide-supplemented diet for 2 months and the effects on immune stimulation, including NK cell activation, were evaluated. Oral administration of silk peptide significantly enhanced the proliferation of mitogen- or IL-2-stimulated splenocytes. In addition, oral silk peptide treatment enhanced the frequency and degree of maturation of NK cells in splenocytes. The same treatment also significantly enhanced the target cell cytolytic activity of NK cells, which was determined by cell surface CD107a expression and intracellular interferon-γ expression. Finally, oral administration of silk peptide stimulated T helper 1-type cytokine expression from splenic lymphocytes. Collectively, our results suggest that silk peptide potentiates NK cell activity in vivo and could be used as a compound for immune-modulating anti-tumor treatment.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (6)
참고문헌 신청
박동선 / 2011 / Improving Effect of Silk Peptides on the Cognitive Function of Rats with Aging Brain Facilitated by D-Galactose / Biomolecules & Therapeutics 19(2):224~230
Tae Kyun Kim / 2011 / Tyrosine-fortified Silk Amino Acids Improve Physical Function of Parkinson’s Disease Rats / Food Science and Biotechnology 20(1):79~84
Mei-sa Wang / 2019 / Silk fibroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells / Acta Pharmacologica Sinica 40(4):522~529
HeynKeyung Chang / 2012 / Lactoferrin Stimulates Mouse Macrophage to Express BAFF via Smad3 Pathway / Immune Network 12(3):84~88
Joung-Ho Moon / 2011 / Resistance to Toxoplasma gondii Infection in Mice Treated with Silk Protein by Enhanced Immune Responses / The Korean Journal of Parasitology 49(3):303~308
Tae Kyun Kim / 2011 / Tyrosine-fortified Silk Amino Acids Improve Physical Function of Parkinson’s Disease Rats / Food Science and Biotechnology 20(1):79~84
Mei-sa Wang / 2019 / Silk fibroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells / Acta Pharmacologica Sinica 40(4):522~529
HeynKeyung Chang / 2012 / Lactoferrin Stimulates Mouse Macrophage to Express BAFF via Smad3 Pathway / Immune Network 12(3):84~88
Joung-Ho Moon / 2011 / Resistance to Toxoplasma gondii Infection in Mice Treated with Silk Protein by Enhanced Immune Responses / The Korean Journal of Parasitology 49(3):303~308
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Journal of Pharmaceutical Investigation
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Antioxidation and anti-inflammatory effects of gamma-irradiated silk sericin and fibroin in H2O2-induced HaCaT Cell
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Cytotoxicity of natural killer cells co-cultured with γ-irradiatedor mitomycin C-treated feeder cells
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Natural Killer Cell Expansion and Cytotoxicity Differ Depending on the Culture Medium Used
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Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity
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Comparison of unprocessed silk cocoon and silk cocoon middle layer membranes for guided bone regeneration
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Comparison of FcRγ-Deficient and CD57+ Natural Killer Cells Between Cord Blood and Adult Blood in the Cytomegalovirus-Endemic Korean Population
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Identification of a novel peptide that selectively binds to Kidney Injury Molecule-1 (KIM-1) by phage displayed peptide library
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UCI(KEPA) : I410-ECN-0101-2019-517-000120544