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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 555 - 561 (7page)
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Background: Kojic acid was used for decades in the cosmetic industry as an antimelanogenic agent. However, there are two major drawbacks of Kojic acid, one is cytotoxicity and second are instability on storage. These limitations led the scientist to synthesize the active Kojic acid peptides.
Objective: In the present study, we synthesize and investigate the effect of five Kojic acid peptides to overcome the limitation of Kojic acid. Methods: The peptide was analyzed and purified by high-performance liquid chromatography and matrix-assisted laser desorption ionization time of flight mass spectroscopy. Further, the tyrosinase activities of the Kojic acid and Kojic acid peptides were compared. The toxicity was measured and the melanin content is recorded in B16F10 mouse melanoma cells.
Results: Maximum tyrosinase activity was measured by Kojic acid peptides. Therefore, Kojic acid peptides were subjected to melanin assay and cytotoxicity assay and finally the stability of the Kojic acid peptide was measured. Conclusion: It was observed that this newly synthesized Kojic acid peptide is stable and potent to inhibit the tyrosinase activity and melanin content of B16F10 mouse melanoma cells without exhibiting cell toxicity. Together, these preliminary results suggest that a further exploration is being needed to establish Kojic acid peptide as antimelanogenic agent.
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참고문헌 (22)
참고문헌 신청
Jones G / 2010 / Beauty imagined : a history of the global beauty industry / Oxford University Press
Noh JM. / 2007 / Kojic acid-tripeptide amide as a new tyrosinase inhibitor / Biopolymers 88:300~307
Slominski A. / 2004 / Melanin pigmentation in mammalian skin and its hormonal regulation / Physiol Rev 84:1155~1228
Breathnach AC. / 1989 / Azelaic acid therapy in disorders of pigmentation / Clin Dermatol 7:106~119
Verallo-Rowell VM. / 1989 / Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma / Acta Derm Venereol Suppl(Stockh) 143:58~61
Noh JM. / 2007 / Kojic acid-tripeptide amide as a new tyrosinase inhibitor / Biopolymers 88:300~307
Slominski A. / 2004 / Melanin pigmentation in mammalian skin and its hormonal regulation / Physiol Rev 84:1155~1228
Breathnach AC. / 1989 / Azelaic acid therapy in disorders of pigmentation / Clin Dermatol 7:106~119
Verallo-Rowell VM. / 1989 / Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma / Acta Derm Venereol Suppl(Stockh) 143:58~61
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