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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.5
- 수록면
- 278 - 280 (3page)
- DOI
- 10.14348/molcells.2023.0043
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초록· 키워드
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Local regulation of the mitochondrial DNA (mtDNA) transcription within the mitochondria contributes to regulate the respiratory activity by sensing the nucleoid distribution. This is a new regulatory respiratory function within the mitochondria. Moreover, the coordination of mitochondrial fission and nucleoid trafficking, mediated by dynamin-related protein 1 (Drp1) and ATPase family AAA domain-containing protein 3A (ATAD3A), regulates the nucleoid distribution. However, defects in the Drp1-mediated fission results in low electron transport chain (ETC) formation due to the low transcription of the mtDNA, while the ATAD3A-mediated nucleoid dispersion led to high ETC formation due to the high transcription of the mtDNA. Additionally, the Drp1-MFF-ATAD3A-nucleoid cascade mediates the communication between the cytosolic mitochondrial fission and mitochondrial matrix nucleoid function. MFF, mitochondrial fission factor.
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