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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 582 - 587 (6page)
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It is well known that oxidative stress participates in neuronal cell death caused production of reactive oxygen species (ROS). The increased ROS is a major contributor to the development of ischemic injury. Indoleamine 2,3-dioxygenase 1 (IDO-1) is involved in the kynurenine pathway in tryptophan metabolism and plays a role as an anti-oxidant. However, whether IDO-1 would inhibit hippocampal cell death is poorly known. Therefore, we explored the effects of cell permeable Tat-IDO-1 protein against oxidative stress-induced HT-22 cells and in a cerebral ischemia/reperfusion injury model. Transduced Tat-IDO-1 reduced cell death, ROS production, and DNA fragmentation and inhibited mitogen-activated protein kinases (MAPKs) activation in H2O2 exposed HT-22 cells. In the cerebral ischemia/ reperfusion injury model, Tat-IDO-1 transduced into the brain and passing by means of the blood-brain barrier (BBB) significantly prevented hippocampal neuronal cell death. These results suggest that Tat-IDO-1 may present an alternative strategy to improve from the ischemic injury.
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참고문헌 (49)
참고문헌 신청
Tas SW / 2007 / Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2, 3-dioxygenase(IDO)induction and immune regulation / Blood 1:1540~1549
Uyttenhove C / 2003 / Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase / Nat Med 9:1269~1274
Wang XF / 2014 / The role of indoleamine 2, 3-dioxygenase(IDO)in immune tolerance : focus on macrophage polarization of THP-1 cells / Cell Immunol 289:42~48
Hirata F / 1977 / Intracellular utilization of superoxide anion by indoleamine 2, 3-dioxygenase of rabbit enterocytes / J Biol Chem 252:2774~1776
Chen Y / 2009 / Kynurenine pathway metabolites in humans : Disease and healthy states / Int J Tryptophan Res 2:1~19
Uyttenhove C / 2003 / Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase / Nat Med 9:1269~1274
Wang XF / 2014 / The role of indoleamine 2, 3-dioxygenase(IDO)in immune tolerance : focus on macrophage polarization of THP-1 cells / Cell Immunol 289:42~48
Hirata F / 1977 / Intracellular utilization of superoxide anion by indoleamine 2, 3-dioxygenase of rabbit enterocytes / J Biol Chem 252:2774~1776
Chen Y / 2009 / Kynurenine pathway metabolites in humans : Disease and healthy states / Int J Tryptophan Res 2:1~19
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