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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 654 - 659 (6page)
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Abstract Antioxidant 1 (ATOX1) protein has been reported to exhibit various protective functions, including antioxidant and chaperone. However, the effects of ATOX1 on the inflammatory response has not been fully elucidated. Thus, we prepared cell permeable Tat-ATOX1 and studied the effects on lipopolysaccharide (LPS)- and 12-O-tetradecanoyl phorbol-13- acetate (TPA)-induced inflammation. Experimental results showed that transduced Tat-ATOX1 protein significantly suppressed LPS-induced intracellular reactive oxygen species (ROS). Also, Tat-ATOX1 protein markedly inhibited LPS- and TPA-induced inflammatory responses by decreasing cyclooxygenase- 2 (COX-2) and inducible nitric oxide synthase (iNOS) and further inhibited phosphorylation of mitogen activated protein kinases (MAPKs; JNK, ERK and p38) and the nuclear factor-kappaB (NF-κB) signaling pathway. These results indicate that the Tat-ATOX1 protein has a pivotal role in inflammation via inhibition of inflammatory responses, suggesting Tat-ATOX1 protein may offer a therapeutic strategy for inflammation.
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참고문헌 (41)
참고문헌 신청
Martinon F / 2009 / The inflammasomes:guardians of the body / Annu Rev Immunol 27:229~265
Medzhitov R / 2008 / Origin and physiological roles of inflammation / Nature 454:428~435
Hiraiwa K / 2013 / Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants / Mediators Inflamm 2013:619523
Fujiwara N / 2005 / Macrophages in inflammation / Curr Drug Targets Inflamm Allergy 4:281~286
Laskin DL / 2011 / Macrophages and tissue injury: agents of defense or destruction / Annu Rev Pharmacol Toxicol 51:267~288
Medzhitov R / 2008 / Origin and physiological roles of inflammation / Nature 454:428~435
Hiraiwa K / 2013 / Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants / Mediators Inflamm 2013:619523
Fujiwara N / 2005 / Macrophages in inflammation / Curr Drug Targets Inflamm Allergy 4:281~286
Laskin DL / 2011 / Macrophages and tissue injury: agents of defense or destruction / Annu Rev Pharmacol Toxicol 51:267~288
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