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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 695 - 699 (5page)
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Cytokine-induced apoptosis inhibitor 1 (CIAPIN1), known as an anti-apoptotic and signal-transduction protein, plays a pivotal role in a variety of biological processes. However, the role of CIAPIN1 in inflammation is unclear. We investigated the protective effects of CIAPIN1 in lipopolysaccharide (LPS)-exposed Raw 264.7 cells and against inflammatory damage induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in a mouse model using cell-permeable Tat-CIAPIN1. Transduced Tat-CIAPIN1 significantly reduced ROS production and DNA fragmentation in LPS-exposed Raw 264.7 cells. Also, Tat- CIAPIN1 inhibited MAPKs and NF-B activation, reduced the expression of Bax, and cleaved caspase-3, COX-2, iNOS, IL-6, and TNF- in LPS-exposed cells. In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF- expression. Therefore, these findings suggest that Tat-CIAPIN1 might lead to a new strategy for the treatment of inflammatory skin disorders.
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참고문헌 (48)
참고문헌 신청
Fan G / 2016 / Anti-inflammatory activity of Tanshinone IIA in LPS-stimulated RAW264. 7macrophages via miRNAs and TLR4-NF-kappaB pathway / Inflammation 39:375~384
Duffield JS / 2003 / The inflammatory macrophage : a story of Jekyll and Hyde / Clin Sci 104:27~38
Chung HY / 2009 / Molecular inflammation as an underlying mechanism of aging : the anti-inflammatory action of calorie restriction / Ageing Res Rev 8:18~30
Korhonen R / 2005 / Nitric oxide production and signaling in inflammation / Curr Drug Targets Inflamm Allergy 4:471~479
Grilli M / 1999 / Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway / Cell Death Differ 6:22~27
Duffield JS / 2003 / The inflammatory macrophage : a story of Jekyll and Hyde / Clin Sci 104:27~38
Chung HY / 2009 / Molecular inflammation as an underlying mechanism of aging : the anti-inflammatory action of calorie restriction / Ageing Res Rev 8:18~30
Korhonen R / 2005 / Nitric oxide production and signaling in inflammation / Curr Drug Targets Inflamm Allergy 4:471~479
Grilli M / 1999 / Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway / Cell Death Differ 6:22~27
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