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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 382 - 387 (6page)
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Reactive oxygen species generated under oxidative stress are involved in neuronal diseases, including ischemia. Glutathione S-transferase pi (GSTpi) is a member of the GST family and is known to play important roles in cell survival. We investigated the effect of GSTpi against oxidative stress-induced hippocampal HT-22 cell death, and its effects in an animal model of ischemic injury, using a cell-permeable PEP-1-GSTpi protein.
PEP-1-GSTpi was transduced into HT-22 cells and significantly protected against H2O2-treated cell death by reducing the intracellular toxicity and regulating the signal pathways, including MAPK, Akt, Bax, and Bcl-2. PEP-1-GSTpi transduced into the hippocampus in animal brains, and markedly protected against neuronal cell death in an ischemic injury animal model. These results indicate that PEP-1-GSTpi acts as a regulator or an antioxidant to protect against oxidative stressinduced cell death. Our study suggests that PEP-1-GSTpi may have potential as a therapeutic agent for the treatment of ischemia and a variety of oxidative stress-related neuronal diseases.
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참고문헌 (44)
참고문헌 신청
Udomsinprasert R / 2005 / Identification, characterization, structure of a new delta class glutathione transferase isoenzyme / Biochem J 388:763~771
Sheehan D / 2001 / Structure, function, evolution of glutathione transferases:implications for classification of non-mammalian members of an ancient enzyme superfamily / Biochem J 36:1~16
Raza H / 2011 / Dual localization of glutathione S-transferase in the cytosol, mitochondria: implications in oxidative stress, toxicity and disease / FEBS J 278:4243~4251
Atkinson HJ / 2009 / Glutathione transferases are structural, functional outliers in the thioredoxin fold / Biochemistry 48:11108~11116
Harrison DJ / 1989 / Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury / J Clin Pathol 42:624~628
Sheehan D / 2001 / Structure, function, evolution of glutathione transferases:implications for classification of non-mammalian members of an ancient enzyme superfamily / Biochem J 36:1~16
Raza H / 2011 / Dual localization of glutathione S-transferase in the cytosol, mitochondria: implications in oxidative stress, toxicity and disease / FEBS J 278:4243~4251
Atkinson HJ / 2009 / Glutathione transferases are structural, functional outliers in the thioredoxin fold / Biochemistry 48:11108~11116
Harrison DJ / 1989 / Distribution of glutathione S-transferase isoenzymes in human kidney: basis for possible markers of renal injury / J Clin Pathol 42:624~628
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