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Transduced Tat-DJ-1 protein inhibits cytokines-induced pancreatic RINm5F cell death
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논문 기본 정보

Type
Academic journal
Author
Journal
KOREAN SOCIETY OF MEDICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY BMB Reports BMB Reports 제49권 제5호 KCI Accredited Journals
Published
2016.1
Pages
297 - 302 (6page)

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Transduced Tat-DJ-1 protein inhibits cytokines-induced pancreatic RINm5F cell death
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Abstract· Keywords

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Loss of pancreatic -cells by oxidative stress or cytokines is associated with diabetes mellitus (DM). DJ-1 is known to as a multifunctional protein, which plays an important role in cell survival. We prepared cell permeable wild type (WT) and mutant type (M26I) Tat-DJ-1 proteins to investigate the effects of DJ-1 against combined cytokines (IL-1, IFN- and TNF-)-induced RINm5F cell death. Both Tat-DJ-1 proteins were transduced into RINm5F cells. WT Tat-DJ-1 proteins significantly protected against cell death from cytokines by reducing intracellular toxicities. Also, WT Tat-DJ-1 proteins markedly regulated cytokines-induced pro- and anti-apoptosis proteins. However, M26I Tat-DJ-1 protein showed relatively low protective effects, as compared to WT Tat-DJ-1 protein. Our experiments demonstrated that WT Tat-DJ-1 protein protects against cytokine-induced RINm5F cell death by suppressing intracellular toxicities and regulating apoptosisrelated protein expression. Thus, WT Tat-DJ-1 protein could potentially serve as a therapeutic agent for DM and cytokine related diseases.
#Cytokines #Protein therapy #Tat-DJ-1 #Toxicity #Wild type and mutants

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References (35)

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Eizirik DL / 2009 / The role of inflammation in insulitis, beta-cell loss in type 1diabetes / Nat Rev Endocrinol 5:219~226 google schola Cnop M / 2007 / Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes / Diabetes Care 30:677~682 google schola Shaw JE / 2010 / Global estimates of the prevalence of diabetes for 2010, 2030 / Diabetes Res Clin Pr 87:4~14 google schola Agrawal NK / 2007 / Cilostazol reduces inflammatory burden, oxidative stress in hypertensive type 2 diabetes mellitus patients / Pharmacol Res 56:118~123 google schola Lundh M / 2013 / Small-molecule inhibition of inflammatory beta cell death / Diabetes Obes Metab 15(Suppl 3):176~184 google schola

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