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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 394 - 399 (6page)
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Human immunodeficiency virus-1 (HIV-1) transactivator of transcription (Tat) is an important viral factor in neuroinflammation. Hindsiipropane B, present in Celastrus hindsii, possesses various biological mechanisms including antiinflammatory activity. In this report, we explored the regulatory activity of hindsiipropane B on HIV-1 Tat-mediated chemokine production and its mode of action in astrocytes. Human immunodeficiency virus-1 (HIV-1) transactivator of transcription (Tat) is an important viral factor in neuroinflammation. Hindsiipropane B, present in Celastrus hindsii, possesses various biological mechanisms including antiinflammatory activity. In this report, we explored the regulatory activity of hindsiipropane B on HIV-1 Tat-mediated chemokine production and its mode of action in astrocytes. Hindsiipropane B significantly alleviated HIV-1 Tat-mediated production of inflammatory chemokines, CCL2, CXCL8, and CXCL10. Hindsiipropane B inhibited expression of HDAC6, which is important regulator in HIV-1 Tat-mediated chemokine production. Hindsiipropane B diminished HIV-1 Tat-mediated reactive oxygen species (ROS) generation and NADPH oxidase activation/expression. Furthermore, hindsiipropane B inhibited HIV-1 Tat-mediated signaling cascades including MAPK, NF-κB, and AP-1. These data suggest that hindsiipropane B exerts its inhibitory effects on HIV-1 Tat-mediated chemokine production via down-regulating the HDAC6-NADPH oxidase-MAPK-NF-κB/AP-1 signaling axis, and could serve as a therapeutic lead compound against HIV-1 Tat-associated neuroinflammation.
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참고문헌 (27)
참고문헌 신청
Yao H / 2010 / HIV neuropathogenesis: a tight rope walk of innate immunity / J Neuroimmune Pharmacol 5:489~495
Ozdener H / 2005 / Molecular mechanisms of HIV-1 associated neurodegeneration / J Biosci 30:391~405
Nookala AR / 2014 / Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes / J Neuroinflammation 11:214
Youn GS / 2014 / Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes / Toxicol Appl Pharmacol 280:42~52
Farina C / 2007 / Astrocytes are active players in cerebral innate immunity / Trends Immunol 28:138~145
Ozdener H / 2005 / Molecular mechanisms of HIV-1 associated neurodegeneration / J Biosci 30:391~405
Nookala AR / 2014 / Molecular mechanisms involved in HIV-1 Tat-mediated induction of IL-6 and IL-8 in astrocytes / J Neuroinflammation 11:214
Youn GS / 2014 / Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes / Toxicol Appl Pharmacol 280:42~52
Farina C / 2007 / Astrocytes are active players in cerebral innate immunity / Trends Immunol 28:138~145
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