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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 617 - 622 (6page)
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초록· 키워드
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Oxidative stress is closely associated with various diseases and is considered to be a major factor in ischemia. NAD(P)H: quinone oxidoreductase 1 (NQO1) protein is a known antioxidant protein that plays a protective role in various cells against oxidative stress. We therefore investigated the effects of cell permeable Tat-NQO1 protein on hippocampal HT-22 cells, and in an animal ischemia model. The Tat-NQO1 protein transduced into HT-22 cells, and significantly inhibited against hydrogen peroxide (H2O2)-induced cell death and cellular toxicities. Tat-NQO1 protein inhibited the Akt and mitogen activated protein kinases (MAPK) activation as well as caspase-3 expression levels, in H2O2 exposed HT-22 cells.
Moreover, Tat-NQO1 protein transduced into the CA1 region of the hippocampus of the animal brain and drastically protected against ischemic injury. Our results indicate that Tat-NQO1 protein exerts protection against neuronal cell death induced by oxidative stress, suggesting that Tat-NQO1 protein may potentially provide a therapeutic agent for neuronal diseases.
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참고문헌 (34)
참고문헌 신청
Vasiliou V / 2006 / Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family / Hum Genomics 2:329~335
Winski SL / 2002 / Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells / Cancer Res 62:1420~1424
Kensler TW / 2007 / Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway / Annu Rev Pharmacol Toxicol 47:89~116
Dinkova-Kostova AT / 2010 / NAD(P)H : quinone acceptor oxidoreductase 1(NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector / Arch Biochem Biophys 501:116~123
Gayam SR / 2016 / An NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo / Nanocacle 8:12307~12317
Winski SL / 2002 / Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells / Cancer Res 62:1420~1424
Kensler TW / 2007 / Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway / Annu Rev Pharmacol Toxicol 47:89~116
Dinkova-Kostova AT / 2010 / NAD(P)H : quinone acceptor oxidoreductase 1(NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector / Arch Biochem Biophys 501:116~123
Gayam SR / 2016 / An NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme responsive nanocarrier based on mesoporous silica nanoparticles for tumor targeted drug delivery in vitro and in vivo / Nanocacle 8:12307~12317
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