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- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제5권 제1호
- 발행연도
- 2017.1
- 수록면
- 41 - 46 (6page)
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Purpose: Drug-induced liver injury is one of the serious adverse reactions resulting in severe morbidity and discontinuation of medications.
Previously, IL-10 gene polymorphism has been reported to be associated with diclofenac-induced hepatitis. In this study, we aimed to investigate the associations between genetic polymorphisms of immune-regulating cytokines (IL-10 and TGF-β1) with antituberculosis drugs (ATD)-induced liver injury Methods: We enrolled 80 patients with ATD-induced liver injury and 238 ATD-tolerant controls. Two single nucleotide polymorphisms (SNP) of IL-10 (-1082A>G, rs1800896; -819T>C, rs1800871) and one promoter SNP of TGF-β1 gene (-509C>T, rs1800469) were genotyped in both groups. Genotype frequencies of these SNPs were compared between case and control groups Results: In 2 promoter SNPs of IL-10 gene, there was no significant difference of genotype frequencies between patients with ATDinduced liver injury and controls. In addition, the genotype frequency of TGF-β1 -509C>T SNP in ATD-induced liver injury patients were not different from those of controls.
Conclusion: In conclusion, there was no significant association between IL-10 and TGF-β1 gene polymorphisms and ATD-induced liver injury. These findings suggest that IL-10 and TGF-β1 do not play important role in the development of ATD-induced liver injury.
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참고문헌 (25)
참고문헌 신청
Aithal GP / 2004 / Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity / Hepatology 39 : 1430 ~ 1440
Aithal GP / 2015 / Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practice / Liver Int 35 : 1801 ~ 1808
Blumberg HM / 2003 / American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis / Am J Respir Crit
Cai F / 2015 / Interleukin-10 -1082
Chen R / 2015 / The association between HLA-DQB1 polymorphism and antituberculosis drug-inducedliver injury: a Case-Control Study / J Clin Pharm Ther 40 : 110 ~ 115
Aithal GP / 2015 / Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practice / Liver Int 35 : 1801 ~ 1808
Blumberg HM / 2003 / American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis / Am J Respir Crit
Cai F / 2015 / Interleukin-10 -1082
Chen R / 2015 / The association between HLA-DQB1 polymorphism and antituberculosis drug-inducedliver injury: a Case-Control Study / J Clin Pharm Ther 40 : 110 ~ 115
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