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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 733 - 738 (6page)
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초록· 키워드
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Objective Brain-derived neurotrophic factor (BDNF) has possible neurobiologic impact on etiology of schizophrenia. We hypothesized that the specific allele or the genotype such as two single nucleotide polymorphisms (SNPs) , 196G/A (rs6265), 11757G/C(rs16917204) is associated with schizophrenia or its clinical features. Methods 241 normal controls and 157 schizophrenia patients are included. The differences in allele or genotype distribution for the patients and normal controls were analyzed. We also analyzed clinical variables among patients. Results We found no significant difference in genotype or allele distributions of two studied SNPs between the patient group and the control group. However, history of suicide attempt was relatively higher in patients with genotype with A allele, compared to patients with genotype G/G for 196G/A (p-value=0.045). Conclusion Our results suggest that it is possible to use BDNF gene allele and genotype as a predictor for suicide attempt in schizophrenia patients. It can help manage the schizophrenia patients regarding suicidal behavior and furthermore, mortality.
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참고문헌 (40)
참고문헌 신청
American Psychiatric Association / 2013 / Diagnostic and statistical manual of mental disorders (DSM-5(R)) / American Psychiatric Pub
Kane J / 1988 / Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine / Arch Gen Psychiatry 45:789~796
Elkis H / 2007 / Treatment-resistant schizophrenia / Psychiatr Clin North Am 30:511~533
Liu X / 1995 / Sensory but not motor neuron deficits in mice lacking NT4 and BDNF / Nature 375:238~241
Riccio A / 1999 / Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons / Science 286:2358~2361
Kane J / 1988 / Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine / Arch Gen Psychiatry 45:789~796
Elkis H / 2007 / Treatment-resistant schizophrenia / Psychiatr Clin North Am 30:511~533
Liu X / 1995 / Sensory but not motor neuron deficits in mice lacking NT4 and BDNF / Nature 375:238~241
Riccio A / 1999 / Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons / Science 286:2358~2361
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