메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

Cytotoxicity of natural killer cells on canine mammary carcinoma cells
Recommendations
Search
Questions

개 유선종양세포에 대한 자연살해세포 독성

논문 기본 정보

Type
Academic journal
Author
Da-Un Jeong (농림축산검역본부) Jeong Su Byeon (농림축산검역본부) Na-Yeon Gu (농림축산검역본부) Moonhee Jung (전남대학교) Eun Hee Kim (전남대학교) Hyung-Seok Kim (전남대학교) In-Soo Cho (농림축산검역본부) Jae-Young Song (농림축산검역본부) Bang-Hun Hyun (농림축산검역본부) Jienny Lee (농림축산검역본부)
Journal
대한수의학회 Korean Journal of Veterinary Research(대한수의학회지) Vol.60 No.1 KCI Accredited Journals SCOPUS
Published
2020.3
Pages
25 - 32 (8page)

Usage

cover
📌
Topic
📖
Background
🔬
Method
🏆
Result
Cytotoxicity of natural killer cells on canine mammary carcinoma cells
Ask AI
Recommendations
Search
Questions

Abstract· Keywords

Report Errors
Natural killer (NK) cells play have a crucial role in the early phase of immune responses against various pathogens. We compared characteristics of canine NK cells against two canine mammary carcinoma cell lines, REM134 and CF41.Mg. REM134 showed higher expression of progesterone receptor, proliferative cell nuclear antigen, Ki67, multiple drug resistance, Bmi-1, c-myc, E-cadherin, and human epidermal growth factor receptor type-2 than that of CF41.Mg. For specific expansion and activation of NK cells, we isolated CD5 negative cells from canine peripheral blood mononuclear cells and co-cultured K562 cells in the presence of interleukin (IL)-2, IL-15, and IL-21 for 21 days. As a result, we found that expression markers of activated NK cells such as NKp30, NKp44, NKp46, NKG2D, CD244, perforin, granzyme B, and tumor necrosis factor alpha were highly upregulated. In addition, we found there was upregulated production of interferon gamma of activated NK cells against target cells such as REM134 and CF41.Mg. Specifically, we observed that cytotoxicity of NK cells against target cells was more sensitively reacted to CF41.Mg than REM134. Based on the results of this study, we recommend the development of an experimental application of CF41Mg, which has not been reported in canine mammary carcinoma research.
#canine #mammary carcinoma #natural killer cells #interferon gamma #cytotoxicity

Contents

Abstract
서론
재료 및 방법
결과
고찰
References

References (0)

Add References
If the reference is being serviced by DBpia, please register through [Add Reference]

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Frequently Viewed Together

Potential application of herbal medicine treatment based on pattern identification for canine cognitive dysfunctional syndrome: a comparative analysis of Korea medicine therapy for patients with dementia
Kyungsook Jung ,  HuiYan Zhao ,  Yujin Choi and others 1 Korean Journal of Veterinary Research(대한수의학회지) 2022 .09
Tumorsphere formation and cancer stem cell characterization of REM134 canine mammary carcinoma cells
Jeong Su Byeon ,  Jienny Lee ,  Da-Un Jeong and others 3 Korean Journal of Veterinary Research(대한수의학회지) 2019 .02
The protective effects of sonicated Bordetella bronchiseptica bacterin on the immunosuppression of spleen cells induced by anti-cancer drugs (5-fluorouracil, doxorubicin, and vincristine)
You-Jeong Lee ,  Hong-Gu Joo Korean Journal of Veterinary Research(대한수의학회지) 2022 .09
Evaluation of conservation of endangered species through somatic cell nuclear technology
Sang Hwan Hyun ,  Yeon Woo Jeong ,  Kyu Chan Hwang and others 2 Korean Journal of Veterinary Research(대한수의학회지) 2015 .09
The antibacterial effect of photo-catalytic titanium dioxide on canine skin
Hwa Seok Chang ,  Ji Eun Kim ,  Dai Jung Chung and others 3 Korean Journal of Veterinary Research(대한수의학회지) 2006 .09

Recently viewed articles

Digitization of Old Chinese Bibles(pre-1950s)
Simon Wong, Sukjoo KimKorean Bible Society2019.04
 전시보육과 도쿄의 전시탁아소를 중심으로
김경옥The Society For Asian Historical Studies2019.04
 A Study on the Developing a New "Output Requirements Model" in Interindustry Analysis: Based on the Circulation System of Production between Final Demand, Total Output, and Final Output
Gim Ho unKorea Research Institute For Human Settlements2008.06
 Clinical Outcome Associated Post-operative Acute Kidney Injury in Abdominal Surgery
Jung-Min Baw, Chang-Yeon JungThe Korean Surgical Society2020.11

Comments(0)

0

Write first comments.

UCI(KEPA) : I410-ECN-0101-2023-528-001318533