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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 59 - 69 (11page)
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Background Cancer patients can be at a higher risk of infection due to drug-resistant bacteria than the general population for various reasons. We performed a retrospective study to evaluate possible risk factors and outcomes of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) bacteremia in cancer patients. Materials and Methods Cases were divided into two groups based on whether or not the isolated strain produced ESBL and multivariable regressions were done to identify possible risk factors of ESBL-KP bacteremia and mortality. For ESBL-producing strain, additional molecular analysis was done. Results 278 cases with KP bacteremia were identified between 2010 and 2012, of which ESBL-producers were 50 (18%). The presence of percutaneous drainage catheter [odds ratio (OR) 4.99, P <0.001] and prior exposure to certain classes of antibiotics including third-generation cephalosporin (OR 2.14, P = 0.03) had significant associations with ESBL-KP bacteremia. Individuals who died within 14 days after the onset of KP bacteremia were more likely to have higher mean Pitt bacteremia score (1.56 in survival group vs. 3.43 in mortality group, P <0.001), hemodialysis (OR 17.03, P = 0.01) and chronic liver disease (OR 5.57, P = 0.01). Although 14-day mortality was higher with ESBL production (OR 2.76, P = 0.04), no significant differences in 30-day mortality (OR 1.67, P = 0.20) and other morbidity indices were observed. 49 ESBL-KP isolates, 65.4% of them produced CTX-M-14 and CTX-M-15 enzymes, and ST711 was the most common. Conclusion There were several differences in clinical characteristics between ESBL-KP and non-ESBL-KP bacteremia in cancer patients, similar to previous reports including non-cancer patients.
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참고문헌 (31)
참고문헌 신청
Montassier E / 2013 / Recent changes in bacteremia in patients with cancer : a systematic review of epidemiology and antibiotic resistance / Eur J Clin Microbiol Infect Dis 32:841~850
Podschun R / 1998 / Klebsiella spp. as nosocomial pathogens : epidemiology, taxonomy, typing methods, and pathogenicity factors / Clin Microbiol Rev 11:589~603
Chetcuti Zammit S / 2014 / Mortality risk score for Klebsiella pneumoniae bacteraemia / Eur J Intern Med 25:571~576
Paterson DL / 2005 / Extended-spectrum beta-lactamases : a clinical update / Clin Microbiol Rev 18:657~686
Schneeweiss S / 2007 / Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis / Arthritis Rheum 56:1754~1764
Podschun R / 1998 / Klebsiella spp. as nosocomial pathogens : epidemiology, taxonomy, typing methods, and pathogenicity factors / Clin Microbiol Rev 11:589~603
Chetcuti Zammit S / 2014 / Mortality risk score for Klebsiella pneumoniae bacteraemia / Eur J Intern Med 25:571~576
Paterson DL / 2005 / Extended-spectrum beta-lactamases : a clinical update / Clin Microbiol Rev 18:657~686
Schneeweiss S / 2007 / Anti-tumor necrosis factor alpha therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis / Arthritis Rheum 56:1754~1764
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