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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 98 - 103 (6page)
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초록· 키워드
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Background: The root of Peucedanum japonicum Thunb., a perennial herb found in Japan, the Philippines, China, and Korea, is used as an analgesic. In a previous study, sec-O-glucosylhamaudol (SOG) showed an analgesic effect. This study was performed to examine the antinociceptive effect of intrathecal SOG in the formalin test. Methods: Male Sprague-Dawley rats were implanted with an intrathecal catheter. Rats were randomly treated with a vehicle and SOG (10 μg, 30 μg, 60 μg, and 100 μg) before formalin injection. Five percent formalin was injected into the hind-paw, and a biphasic reaction followed, consisting of flinching and licking behaviors (phase 1, 0−10 min; phase 2, 10−60 min). Naloxone was injected 10 min before administration of SOG 100 μg to evaluate the involvement of SOG with an opioid receptor. Dose-responsiveness and ED50 values were calculated. Results: Intrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of 30 μg and maximum effects were achieved at a dose of 100 μg in both phases. The ED50 value (95% confidence intervals) of intrathecal SOG was 30.3 (25.8−35.5) μg during phase 1, and 48.0 (41.4−55.7) during phase 2. The antinociceptive effects of SOG (100 μg) were significantly reverted at both phases of the formalin test by naloxone. Conclusions: These results demonstrate that intrathecal SOG has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor. (Korean J Pain 2017; 30: 98-103)
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Chen IS / 1996 / Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum / Phytochemistry 41 : 525 ~ 530
Colucci M / 2008 / New insights of dimethyl sulphoxide effects(DMSO)on experimental in vivo models of nociception and inflammation / Pharmacol Res 57 : 419 ~ 425
Hisamoto M / 2003 / Antioxidant compounds from the leaves of Peucedanum japonicum thunb / J Agric Food Chem 51 : 5255 ~ 5261
Hunskaar S / 1987 / The formalin test in mice: dissociation between inflammatory and non-inflammatory pain / Pain 30 : 103 ~ 114
Ikeshiro Y / 1992 / Dihydropyranocoumarins from roots of Peucedanum japonicum / Phytochemistry 31 : 4303 ~ 4306
Colucci M / 2008 / New insights of dimethyl sulphoxide effects(DMSO)on experimental in vivo models of nociception and inflammation / Pharmacol Res 57 : 419 ~ 425
Hisamoto M / 2003 / Antioxidant compounds from the leaves of Peucedanum japonicum thunb / J Agric Food Chem 51 : 5255 ~ 5261
Hunskaar S / 1987 / The formalin test in mice: dissociation between inflammatory and non-inflammatory pain / Pain 30 : 103 ~ 114
Ikeshiro Y / 1992 / Dihydropyranocoumarins from roots of Peucedanum japonicum / Phytochemistry 31 : 4303 ~ 4306
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