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Objectives: The baobab tree is a multipurpose, widely-used species with medicinal properties and numerous food uses. The aim of study was to evaluate the effect of oral administration of baobab on the formalin-induced inflammatory pain in rat model injected into the orofacial regions. Methods: Male Sprague-Dawley rats weighing 260-280 g were used. Pain in the orofacial region was induced using two models, 5% formalin was injected 50 μl subcutaneously or 30 μl in temporomandibular joint (TMJ), respectively. Rats were divided into 4 groups (n=6); formalin, formalin after distilled water (vehicle) or baobab (150, 300 mg/kg). The number of noxious behavioral responses with scratching the facial region was recorded for 9 successive 5-min intervals following formalin injection. Results: There was no significant difference in the first response to the pain between the formalin induced group and the drug administration group. However, in the secondary infusion group, all of the pain medication were responded (Bao 150, 300 mg/kg) (p<0.05). Conclusions: The results showed analgesic effect of baobab on formalin-induced orofacial inflammatory pain. This suggests that the natural product is an effective alternative to the postinflammatory pain control.
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참고문헌 (24)
참고문헌 신청
Barretto SR / 2013 / Evaluation of anti-nociceptive and anti- inflammatory activity of low-level laser therapy on temporomandibular joint inflammation in rodents / J Photoch
Buchmann C / 2010 / The importance of baobab (Adansonia digitata L.)in rural West African subsistence-suggestion of a cautionary approach to international market export of ba
Cairns BE / 2010 / Pathophysiology of TMD pain-basic mechanisms and their implications for pharmacotherapy / J Oral Rehabil 37 : 391 ~ 410
Choi JL / 1995 / The study for treatment fo temporo-mandibular joint pain / The Korean Journal of Pain 8 (1) : 86 ~ 92
Codjia JTC / 2003 / Diversite et valorisation au niveau local des ressources ve ge tales forestie res alimentaires du Benin / Cahiers Agricultures 12 : 321 ~ 331
Buchmann C / 2010 / The importance of baobab (Adansonia digitata L.)in rural West African subsistence-suggestion of a cautionary approach to international market export of ba
Cairns BE / 2010 / Pathophysiology of TMD pain-basic mechanisms and their implications for pharmacotherapy / J Oral Rehabil 37 : 391 ~ 410
Choi JL / 1995 / The study for treatment fo temporo-mandibular joint pain / The Korean Journal of Pain 8 (1) : 86 ~ 92
Codjia JTC / 2003 / Diversite et valorisation au niveau local des ressources ve ge tales forestie res alimentaires du Benin / Cahiers Agricultures 12 : 321 ~ 331
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