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논문 기본 정보

자료유형
학술저널
저자정보
Ahmad Rastegarian (Jahrom University of Medical Sciences) Hassanali Abedi (Jahrom University of Medical Sciences) Hossein K. Jahromi (Jahrom University of Medical Sciences) Safar Zarei (Jahrom University of Medical Sciences Jahrom Iran) Arash Nematollahi (Jahrom University of Medical Sciences) Esrafil Mansouri (Ahvaz Jundishapur University of Medical Sciences) Hadi Sameni (Jahrom University of Medical Sciences)
저널정보
대한약침학회 Journal of Acupuncture & Meridian Studies Journal of Acupuncture & Meridian Studies Vol.13 No.1
발행연도
2020.1
수록면
19 - 24 (6page)

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Melissa officinalis (MO) is one of the oldest herbal medicines commonly used in traditional medicine, which some studies have investigated for its analgesic effect. This study is an attempt to investigate the effects of intrathecal administration of Melissa officinalis on the pain induced by heat and formalin. In this experimental study, 70 male Wistar rats with an average weight of 270-320 g were randomly divided into five groups: control; sham that received 25 ml of saline through the spinal catheter; and three experimental groups that received 5, 10 or 20 mg/kg M. officinalis via the spinal catheter respectively. Five days after catheterization of the spinal cord from the lumbar region under anesthesia, the effects of Intrathecal administration of M. officinalis on heat- and formalin-induced pain were evaluated. Data were analyzed by using one-way ANOVA. Intrathecal injection of M. officinalis blocked heat-induced pain compared to sham group (p Z 0.001). Maximum analgesia was observed 30 min after the injection. Furthermore, intrathecal administration of MO alleviated both acute (p Z 0.007) and chronic (p Z 0.001) phases of formalin-induced pain. Motor block was not observed in any of the above mentioned groups. The results showed that intrathecal administration of MO could significantly improve hot-water and formalininduced pain in male Wistar rats.

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