지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 478 - 485 (8page)
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초록· 키워드
오류제보하기
Background: Cimifugin is one of the components of the root of Saposhnikovia divaricata. The extract derived from S. divaricata is traditionally used as an analgesic. This study was conducted to evaluate the analgesic effect of intrathecal cimifugin in the formalin test.Methods: Male Sprague–Dawley rats (n = 20) were randomized into four groups for intrathecal administration of 70% dimethylsulfoxide and various doses of cimifugin (100 μg, 300 μg, and 1,000 μg). The typical flinch response after the injection of 5% formalin into the hind paw was assessed in two distinct phases: phase 1 until 10 min, and phase 2 from 10 min to 60 min. ED50 values were calculated via linear regression.Results: Intrathecal cimifugin significantly reduced the flinch response in both phases of the formalin test. Significant antinociceptive effects of cimifugin were found with the dose of 300 μg in phase 1 and the dose of 100 μg in phase 2. The ED50 value (95% confidence intervals) of intrathecal cimifugin was 696.1 (360.8–1,342.8) μg during phase 1 and 1,242.8 (42.0–48,292.5) μg during phase 2.Conclusions: Intrathecal cimifugin has an antinociceptive effect against formalin-induced pain. Cimifugin has an anti-inflammatory effect at low concentrations, and non-inflammatory analgesic effect at higher concentrations.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Watkins LR / 2001 / Glial activation : a driving force for pathological pain / Trends Neurosci 24:450~455
Gautam R / 2009 / Recent developments in anti-inflammatory natural products / Med Res Rev 29:767~820
Vijaya Bhargavi M / 2017 / Coumarins and chromones : a remarkable scaffolds for anti-inflammatory activity / J Pharm Sci Res 9:1483~1489
Li Y / 2012 / Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats / Biomed Chromatogr 26:1234~1240
Hisamoto M / 2003 / Antioxidant compounds from the leaves of Peucedanum japonicum thunb / J Agric Food Chem 51:5255~5261
Gautam R / 2009 / Recent developments in anti-inflammatory natural products / Med Res Rev 29:767~820
Vijaya Bhargavi M / 2017 / Coumarins and chromones : a remarkable scaffolds for anti-inflammatory activity / J Pharm Sci Res 9:1483~1489
Li Y / 2012 / Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats / Biomed Chromatogr 26:1234~1240
Hisamoto M / 2003 / Antioxidant compounds from the leaves of Peucedanum japonicum thunb / J Agric Food Chem 51:5255~5261
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