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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 147 - 153 (7page)
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초록· 키워드
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The aim of the present study was to evaluate the central antinociceptive effects of eugenol after intraperitoneal administration. Experiments were carried out using male Sprague-Dawley rats. Subcutaneous injection of 5% formalin-induced nociceptive behavioral responses was used as the pain model. Subcutaneous injection of 5% formalin significantly produced nociceptive responses by increasing the licking time during nociceptive behavior. Subsequent intraperitoneal injection of 100 mg/kg of eugenol led to a significant decrease in the licking time. However, low dose of eugenol (50 mg/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. Intrathecal injection of 30 μg of naloxone, an opioid receptor antagonist, significantly blocked antinociceptive effects produced by intraperitoneal injection of eugenol. Neither intrathecal injection of methysergide (30 μg), a serotonin receptor antagonist nor phentolamine (30 μg), an α-adrenergic receptor antagonist influenced antinociceptive effects of eugenol, as compared to the vehicle treatment. These results suggest that central opioid pathway participates in mediating the antinociceptive effects of eugenol.
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참고문헌 (46)
참고문헌 신청
Li W / 2006 / Inhibitory action of eugenol compounds on the production of nitric oxide in RAW264.7 macrophages / Biomed Res 27:69~74
Kim SS / 2003 / Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW 264.7 cells / Life Sci 73:337~348
Briseno BM / 1990 / Root canal sealer cytotoxicity on human gingival fibroblasts. 1. Zinc oxide-eugenol-based sealers / J Endod 16:383~386
Goerig AC / 1980 / The pulpal response to ZOE with stock eugenol versus ZOE with purified eugenol / Oral Surg Oral Med Oral Pathol 50:557~562
Horsted P / 1981 / Capping of monkey pulps with Dycal and a Ca-eugenol cement / Oral Surg Oral Med Oral Pathol 52:531~553
Kim SS / 2003 / Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW 264.7 cells / Life Sci 73:337~348
Briseno BM / 1990 / Root canal sealer cytotoxicity on human gingival fibroblasts. 1. Zinc oxide-eugenol-based sealers / J Endod 16:383~386
Goerig AC / 1980 / The pulpal response to ZOE with stock eugenol versus ZOE with purified eugenol / Oral Surg Oral Med Oral Pathol 50:557~562
Horsted P / 1981 / Capping of monkey pulps with Dycal and a Ca-eugenol cement / Oral Surg Oral Med Oral Pathol 52:531~553
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