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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 191 - 197 (7page)
이용수
초록· 키워드
오류제보하기
The present study was to evaluate effects of vitamin E on intravenous administration of lidocaine-induced antinociception.
Experiments were carried out using male Sprague-Dawley rats. Orofacial formalin-induced nociceptive behavioral responses were used as the orofacial animal pain model.
Subcutaneous injection of formalin produced significant nociceptive scratching behavior. Intraperitoneal injection of 5 and 10 mg/kg of lidocaine attenuated formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. Intraperitoneal injection of 1 g/kg of vitamin E also attenuated the formalin-induced nociceptive behavior in the 2nd phase, compared to the vehicle-treated group. However, low dose of vitamin E (0.5 g/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. The present study also investigated effects of intraperitoneal injection of both vitamin E and lidocaine on orofacial formalin-induced behavioral responses. Vehicle treatment affected neither formalin-induced behavioral responses nor lidocaineinduced antinociceptive effects. However, intraperitoneal injection of 0.5 g/kg of vitamin E enhanced the lidocaineinduced antinociceptive effects in the 2nd phase compared to the vehicle-treated group. Intraperitoneal injection of naloxone, an opioid receptor antagonist, did not affect antinociception produced by intraperitoneal injections of both vitamin E and lidocaine. These results suggest that treatment with vitamin E enhances the systemic treatment with lidocaine-induced antinociception and reduces side effects when systemically treated with lidocaine. Therefore, the combined treatment with vitamin E and lidocaine is a potential therapeutic for chronic orofacial pain.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Lauretti GR / 2008 / Mechanisms of analgesia of intravenous lidocaine / Rev Bras Anestesiol 58:280~286
Sheu SS / 1985 / Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity / Circ Res 57:578~590
W. A. Catterall / 2001 / PHYSIOLOGY: A One-Domain Voltage-Gated Sodium Channel in Bacteria / Science 294(5550):2306~2308
Abram SE / 1994 / Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat / Anesthesiology 80:383~391
Araujo MC / 2003 / Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions / Pain 103:21~29
Sheu SS / 1985 / Lidocaine's negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity / Circ Res 57:578~590
W. A. Catterall / 2001 / PHYSIOLOGY: A One-Domain Voltage-Gated Sodium Channel in Bacteria / Science 294(5550):2306~2308
Abram SE / 1994 / Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat / Anesthesiology 80:383~391
Araujo MC / 2003 / Multiple phases of relief from experimental mechanical allodynia by systemic lidocaine: responses to early and late infusions / Pain 103:21~29
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