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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 405 - 416 (12page)
- DOI
- 10.3344/kjp.2021.34.4.405
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초록· 키워드
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Background: This study investigated the effect of intrathecal Sec-O-glucosylhamaudol (SOG) on the p38/c-Jun N-terminal kinase (JNK) signaling pathways, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-related inflammatory responses, and autophagy in a spinal nerve ligation (SNL)-induced neuropathic pain model.
Methods: The continuous administration of intrathecal SOG via an osmotic pump was performed on male Sprague?Dawley rats (n = 50) with SNL-induced neuropathic pain. Rats were randomized into four groups after the 7th day following SNL and treated for 2 weeks as follows (each n = 10): Group S, sham-operated; Group D, 70% dimethylsulfoxide; Group SOG96, SOG at 96 μg/day; and Group SOG192, SOG at 192 μg/day. The paw withdrawal threshold (PWT) test was performed to assess neuropathic pain. Western blotting of the spinal cord (L5) was performed to measure changes in the expression of signaling pathway components, cytokines, and autophagy. Additional studies with naloxone challenge (n = 10) and cells were carried out to evaluate the potential mechanisms underlying the effects of SOG.
Results: Continuous intrathecal SOG administration increased the PWT with p38/ JNK mitogen-activated protein kinase (MAPK) pathway and NF-κB signaling pathway inhibition, which induced a reduction in proinflammatory cytokines with the concomitant downregulation of autophagy.
Conclusions: SOG alleviates mechanical allodynia, and its mechanism is thought to be related to the regulation of p38/JNK MAPK and NF-κB signaling pathways, associated with autophagy during neuroinflammatory processes after SNL.
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참고문헌 (35)
참고문헌 신청
Austin PJ / 2010 / The neuro-immune balance in neuropathic pain : involvement of inflammatory immune cells, immune-like glial cells and cytokines / J Neuroimmunol 229:26~50
Ellis A / 2013 / Neuroinflammation and the generation of neuropathic pain / Br J Anaesth 111:26~37
Chen W / 2017 / Upregulated TLR3 promotes neuropathic pain by regulating autophagy in rat with L5 spinal nerve ligation model / Neurochem Res 42:634~643
Dobrek L / 2011 / Glutamate NMDA receptors in pathophysiology and pharmacotherapy of selected nervous system diseases / Postepy Hig Med Dosw (Online) 65:338~346
Shih RH / 2015 / NF-kappaB signaling pathways in neurological inflammation : a mini review / Front Mol Neurosci 8:77
Ellis A / 2013 / Neuroinflammation and the generation of neuropathic pain / Br J Anaesth 111:26~37
Chen W / 2017 / Upregulated TLR3 promotes neuropathic pain by regulating autophagy in rat with L5 spinal nerve ligation model / Neurochem Res 42:634~643
Dobrek L / 2011 / Glutamate NMDA receptors in pathophysiology and pharmacotherapy of selected nervous system diseases / Postepy Hig Med Dosw (Online) 65:338~346
Shih RH / 2015 / NF-kappaB signaling pathways in neurological inflammation : a mini review / Front Mol Neurosci 8:77
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