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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 196 - 202 (7page)
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Transforming growth factor-β1 (TGF-β1) can act as both a tumor suppresor and a stimulator of tu-mor progresion. We have examined the relation-ship betwen polymorphisms of the TGF-β1 gene and the risk of hepatocelular carcinoma (HC) in patients with chronic hepatis B virus (HBV) in-fection. A total of 1,237 Korean subjects were prospectively enroled; 1,046 patients with chronic HBV infection and 191 healthy controls with no evidence of recent or remote HBV infection. The out (n = 809) and those with HC (n = 2 3 7 ) . S i n g l e nucleotide polymorphisms (SNPs) of TGF-β1 were searched for and genotyped using the single base extension method. In Korean subjects, only two SNPs were found among the seven known poly-morphisms of TGF-β1, at position -509 and in co-don 10. The risk of HCC was significantly lower in patients with the T/T or C/T genotypes than in those with the C/C genotypes at position -509 (P ＜ 0.02), and also lower among those with the the Leu/Leu genotypes in codon 10 (P ＜ 0.007). Haplotype analysis revealed that the possession of [-509C＞ T; L10P] conferred a decreased likeli-hod of HCC (OR = 0.74; 95% CI, 0.59-0.93; P =0.008). In conclusion, the presence of the TGF-β1 -509C＞ T promoter or of the L10P polymor-phism, and the combination of both [-509C＞ T; L10P] as a haplotype were strongly associated with a reduced risk of HC in patients with chronic HBV infection.
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