메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제10호
발행연도
2008.1
수록면
1,722 - 1,728 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
The natural course of chronic hepatitis B (CH-B) virus infection is reportedly variable, and the long-term outcomes in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B infection are distinct from HBeAg-positive chronic hepatitis. However, the molecular virological factors that contribute to the progression of liver disease in the south Indian setting remain largely unclear. We prospectively studied 679 consecutive patients for HBsAg, HBeAg, anti-HBe, and HBV DNA by qualitative PCR. Randomly selected samples were subjected to bidirectional sequencing to reveal core/precore variants. Of the total 679 chronic HBV cases investigated, 23% (154/679) were replicative HBV carriers. Furthermore, amongst the 560 HBV DNA samples analyzed, 26% (146/560) were viremic. Among the 154 HBeAg positive cases, HBV DNA was positive in 118 cases (77%), significantly (p<0.001) higher than the anti-HBe positive (7%) (28/406) cases. Significant increase in liver disease (p<0.01) with ALT enzyme elevation (p<0.001) was observed in both HBe and anti-HBe viremic cases. Interestingly, low frequencies of mutations were seen in the precore region of the HBV strains studied. HBV precore and core promoter variants were less often detected in subjects with “e” negative chronic HBV infection and, therefore, may not have a prognostic role in determining liver disease sequelae in this part of tropical India.
#Hepatitis B virus #HBV #India #precore/core mutants

목차

등록된 정보가 없습니다.

참고문헌 (1)

참고문헌 신청
Acharya, S. K. / 2005 / Management of chronic hepatitis B: The Indian perspective. Trop / Gastroenterol 26 : 171 ~ 172 | 2. [학술지(정기간행물)] - Aggarwal, R. / 2003 / Assessment of cost effectiveness of universal hepatitis B immunization in a low income country with intermediate endemicity using a Markov model / Hepatol 38 : 215 ~ 222 | 3. [학술지(정기간행물)] - Akarca, U. S. / 1995 / Naturally occurring hepatitis B virus core gene mutations / Hepatology 22 : 50 ~ 60 | 4. [학술지(정기간행물)] - Banerjee, A. / 2005 / Nucleic acid sequence analysis of basal core promoter/precore/core region of hepatitis B virus isolated from chronic carriers of the virus from Kolkata, eastern India: Low frequency of mutation in the precore region / Intervirology 48 : 389 ~ 399 | 5. [학술지(정기간행물)] - Bertoletti, A. / 1994 / Natural variants of cytotoxic epitopes are T-cell receptor antagonist for antiviral cytotoxic T-cells / Nature 369 : 407 ~ 410 | 6. [학술지(정기간행물)] - Chan, H. L. Y. / 2000 / Hepatitis B e antigen negative chronic hepatitis B in Hong Kong / Hepatology 31 : 763 ~ 768 | 7. [학술지(정기간행물)] - Chauhan, R. / 2006 / Basal core promoter, precore region mutations of HBV and their association with e antigen, genotype, and severity of liver disease in patients with chronic hepatitis B in India. J. Med / Virol 78 : 1047 ~ 1054 | 8. [학술지(정기간행물)] - Chowdhury, A. / 2005 / Community-based epidemiology of hepatitis B virus infection in West Bengal, India: Prevalence of hepatitis B e antigen-negative infection and associated viral variants. J. Gastroenterol / Hepatol 20 : 1712 ~ 1720 | 9. [학술지(정기간행물)] - Chowdhury, A. / 1999 / Prevalence of hepatitis B infection in the general population: A rural community based study. Trop / Gastroenterol 20 : 75 ~ 77 | 10. [학술지(정기간행물)] - Chuang, W. L. / 1993 / Precore mutations and core clustering mutations in chronic hepatitis B virus infection / Gasteroenterology 104 : 263 ~ 271 | 11. [학술지(정기간행물)] - Dumpis, U. / 2001 / Prevalence of HBV core promoter/ precore/core mutations in Gambian chronic carriers. J. Med / Virol 65 : 664 ~ 670 | 12. [단행본] - Fagan, E. A. / 1994 / Candidate hepatitis F in sporadic non-A, non-B acute liver failure: Exclusion in liver of hepatitis viruses A, E, C, and B by polymerase chain reaction, pp. 73-76. In K. Nishioka, H. Susuki, S. Mishiro, and T. Oda (eds.), Viral Hepatitis and Liver Disease / Springer-Verlag | 13. [학술지(정기간행물)] - Funk, M. L. / 2002 / Worldwide epidemiology of HBeAg negative chronic hepatitis B and associated precore and core promoter variants / Viral Hepat 9 : 52 ~ 61 | 14. [학술지(정기간행물)] - Gandhe, S. S. / 2003 / Hepatitis B virus: Prevalence of precore/core promoter mutants in different clinical categories of Indian patients / Viral Hepat 10 : 367 ~ 382 | 15. [단행본] - Hadziyannis, S. J. / 1991 / Immunopathogenesis and natural course of anti-HBe positive chronic hepatitis with replicating B virus, pp. 673-676. In F. B. Hollinger, S. M. Lemon, and H. S. Margolis (eds.). Viral Hepatitis and Liver Disease / Williams and Wilkins | 16. [학술지(정기간행물)] - Ikeda, K. / 2006 / Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase / Am. J. Med 119 : 977 ~ 985 | 17. [학술지(정기간행물)] - Irshad, M. / 1994 / Status of hepatic viral markers in patients with acute and chronic liver diseases in northern India / Intervirology 37 : 369 ~ 372 | 18. [학술지(정기간행물)] - Jain, R. C. / 1992 / Prevalence of hepatitis surface antigen among rural population of Loni area in Ahmednagar district of Western Maharashtra. J. Assoc / Physicians India 40 : 390 ~ 391 | 19. [학술지(정기간행물)] - Kao, J. H. / 2002 / Clinical and virological aspects of blood donors infected with hepatitis B virus genotypes B and C. J. Clin / Microbiol 40 : 22 ~ 25 | 20. [학술지(정기간행물)] - Lok, A. S. F. / 2002 / Chronic hepatitis B. N. Engl / Med 346 : 1682 ~ 1683 | 21. [학술지(정기간행물)] - Merican, I. / 2000 / Chronic hepatitis B virus infection in Asian countries. J. Gastroenterol / Hepatol 15 : 1356 ~ 1361 | 22. [학술지(정기간행물)] - Mital, V. N. / 1980 / Pattern of hepatitis B antigen-contact and carrier state in Northern India. J. Indian Med / Assoc 74 : 105 ~ 107 | 23. [학술지(정기간행물)] - Murhekar, M. V. / 2000 / Prevalence of hepatitis B infection among the primitive tribes of Andaman and Nicobar Islands. Indian J. Med / Res 111 : 199 ~ 203 | 24. [학술지(정기간행물)] - Sarin, S. K. / 2001 / Profile of hepatocellular carcinoma in India: An insight into the possible etiologic associations. J. Gastroenterol / Hepatol 16 : 666 ~ 673 | 25. [학술지(정기간행물)] - Sobeslavsky, O. / 1980 / Prevalence of markers of hepatitis B virus infection in various countries: A WHO collaborative study. Bull / World Health Organ 58 : 621 ~ 628 | 26. [학술지(정기간행물)] - Tandon, B. N. / 1991 / Prevalence of HBsAg and anti-HBs in children and strategy suggested for immunisation in India. Indian / Med. Res 93 : 337 ~ 339 | 27. [학술지(정기간행물)] - Tandon, B. N. / 1996 / Seroepidemiology of HBV and HCV in India. Strategy for control of maternal transmission of HBV and its effect. Screening methods of blood donors for control of post transfusion hepatitis and their effects. Info. Hepatol / Communic 5 : 14 ~ 18 | 28. [학술지(정기간행물)] - Tandon, B. N. / 1996 / Epidemiology of hepatitis B virus infection in India / Gut 38 : S56 ~ S59 | 29. [단행본] - Thyagarajan, S. P. / 1996 / Prevalence of HBV in general population of India, pp. 5-16 In S. K. Sarin and A. K. Singhal (eds). Hepatitis B in India: / CBS | 30. [학술지(정기간행물)] - Valliammai, T. / 1995 / Precore and core mutations in HBV from individuals in India with chronic infection. J. Med / Virol 45 : 321 ~ 325 | 31. [학술지(정기간행물)] - Whalley, S. A. / 2004 / Evolution of hepatitis B virus during primary infection in humans: Transient generation of cytotoxic T-cell mutants / Gastroenterology 127 : 1131 ~ 1138 | 32. [학술지(정기간행물)] - Yoo, B. C. / 2003 / Precore and core promoter mutations of hepatitis B virus and hepatitis B e antigen negative chronic hepatitis B in Korea / Hepatol 38 : 98 ~ 103 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0