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논문 기본 정보
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- 2017.1
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Hepatitis B virus (HBV) has an important role in the development of human hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV-encoded X protein (HBx) can induce both genetic alterations in tumor suppressor genes and oncogenes, as well as epigenetic aberrations in HCC pathogens. Non-coding RNAs (ncRNAs) mainly include microRNAs and long non-coding RNAs (lncRNAs). Although ncRNAs cannot code proteins, growing evidence has shown that they have various important biological functions in cell proliferation, cell cycle control, anti-apoptosis, epithelial–mesenchymal transition, tumor invasion and metastasis. This review summarizes the current knowledge regarding the mechanisms and emerging roles of ncRNAs in the pathogenesis of HBV-related HCC. Accumulated data have shown that ncRNAs regulated by HBx have a crucial role in HBV-associated hepatocarcinogenesis. The findings of these studies will contribute to more clinical applications of HBV-related ncRNAs as potential diagnostic markers or as molecular therapeutic targets to prevent and treat HBV-related HCC.
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참고문헌 (28)
참고문헌 신청
Arbuthnot P / 2001 / Hepatitis B virus and hepatocellular carcinoma / Int J Exp Pathol 82 : 77 ~ 100
Bartel DP. / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Baylin SB / 2005 / DNA methylation and gene silencing in cancer / Nat Clin Pract Oncol 2 (Suppl 1) : S4 ~ S11
Carthew RW / 2009 / Origins and Mechanisms of miRNAs and siRNAs / Cell 136 : 642 ~ 655
Diao J / 2001 / X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarci
Bartel DP. / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Baylin SB / 2005 / DNA methylation and gene silencing in cancer / Nat Clin Pract Oncol 2 (Suppl 1) : S4 ~ S11
Carthew RW / 2009 / Origins and Mechanisms of miRNAs and siRNAs / Cell 136 : 642 ~ 655
Diao J / 2001 / X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarci
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Pathogenic diversity of RNA variants and RNA variation-associated factors in cancer development
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