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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제6호
- 발행연도
- 2004.1
- 수록면
- 1,267 - 1,274 (8page)
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초록· 키워드
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Colostrum contains various kinds of cytokinesincluding TGF-β that has potent regulatory effects on cells ofthe immune system. We compared the levels of TGF-β1 andTGF-β2 in bovine and human colostrum. Based on theisoform-specific ELISA, bovine colostrum collected on day 1post-delivery retained 53.71±29.55 ng/ml of TGF-β1 and40.41±21.78 μg/ml of TGF-β2 (n=4), while in human, 381.45±158.24 ng/ml of TGF-β1 and 41.47±9.63 ng/ml of TGF-β2(n=5). Thus, dominant TGF-β isoforms were completelyopposite between human and bovine colostrum samples. Theconcentrations of both isoforms declined as lactation proceeded.Biological activities of the colostrum samples were determinedusing an MV1LU cell line. Consistent with the result from theimmunoassay, TGF-β1 in human and TGF-β2 in bovinecolostrum were responsible for the antiproliferative activityagainst MV1LU cells. Furthermore, bovine colostrum increasedIgA secretion by LPS-stimulated mesenteric lymph node(MLN) cells, and this effect was abrogated by either anti-TGF-β2 antibody or combined anti-TGF-β1/β2 antibody, butnot by anti-TGF-β1 antibody alone. Similarly, TGF-β2 in bovinecolostrum enhanced the Ig germ line (GL) promoter activity,which is the earliest event toward IgA isotype switching.Taken together, these results suggest that TGF-β isoforms,differentially expressed in human and bovine colostrum, maypromote IgA isotype production in the neonatal intestine.
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참고문헌 (25)
참고문헌 신청
29 mu / 1991 / Effect of cytokines onswitching to IgA and alpha germline transcripts in theB lymphoma I Transforming growth factor-betaactivates transcription of the unrearr
A / 1990 / A component of the large latentcomplex of TGF-beta 1 with multiple repeat sequences miyazo : 1051 ~ 1061
A / 1990 / Mechanism for transforming growth factor beta and IL-2enhancement of IgA expression in lipopolysaccharidestimulatedB cell cultures immu (l) : 952 ~ 959
Bartram / 2001 / Double-outletright ventricle and overriding tricuspid valve reflectdisturbances of looping, myocardialization, endocardialcushion differentiation, and apopto
Dart / 1989 / Immunodetection and quantitationof the two forms of transforming growth factor-beta secreted by cells in culture : 79 ~ 86
A / 1990 / A component of the large latentcomplex of TGF-beta 1 with multiple repeat sequences miyazo : 1051 ~ 1061
A / 1990 / Mechanism for transforming growth factor beta and IL-2enhancement of IgA expression in lipopolysaccharidestimulatedB cell cultures immu (l) : 952 ~ 959
Bartram / 2001 / Double-outletright ventricle and overriding tricuspid valve reflectdisturbances of looping, myocardialization, endocardialcushion differentiation, and apopto
Dart / 1989 / Immunodetection and quantitationof the two forms of transforming growth factor-beta secreted by cells in culture : 79 ~ 86
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