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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 694 - 702 (9page)
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Hepatocellular carcinoma (HCC) is one of the most common malignant cancers closely associated with chronic infection by the hepatis B virus (HBV) or the hepatitis C virus (HCV) throughout the world. In this study, the genetic associations of 20 known polymorphisms in eight candidate genes, including AGT), cadherin 1 (CDH1), cyclooxy-genase 2 (COX2), monocyte chemotactic protein-1 (MCP1), multidrug resistance 1 (MDR1), chemokine ligand 5 (RANTES), thrombospondin 2 (THBS2), and thrombospondin 4 (THBS4), were analyzed in a large chronic hepatitis B cohort (n=1,095) recruited from the Korean population. In addition, three polymor-phisms in chemokine receptor 4 (CXCR4) and vimentin (VIM) identified in this study were also genotyped. Using logistic regression analysis con-trolling possible confounding factors, one common (freq.=0.367) promoter polymorphism of MCP1 (MCP1-2518G>A) among analyzed polymorphisms was significantly associated with clearance of HBV infection. The frequency of homozygotes for the MCP1-2518A alle ( MCP1-2518A/A) among chronic hepatitis B virus (HBV) carrier patients was sig-nificantly higher than that among spontaneously recovered (SR) subjects (17.7% vs. 10.4%)(OR=1.78, P=0.004). Our findings imply a plausible explanation for the contribution of host genetic determinants to the variable outcome of HBV infection, which might provide valuable information for future genetic study in this area.
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참고문헌 (29)
참고문헌 신청
/ / Hepatitis B virus markers in Chinese twins : 737 ~ 41
/ 1995 / Hepatitis B virus immunopathogenesis 13 : 29 ~ 60
/ 1998 / Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis 186 : 82 ~ 89
/ 1998 / Interferon decreases hepatocellular carcinogenesis in pa-tients with cirrhosis caused by the hepatitis B virus 82 : 827 ~ 835
/ 1999 / Polymorphism in RANTES chemokine promoter affects HIV-1 di
/ 1995 / Hepatitis B virus immunopathogenesis 13 : 29 ~ 60
/ 1998 / Distinct patterns of chemokine expression are associated with leukocyte recruitment in alcoholic hepatitis and alcoholic cirrhosis 186 : 82 ~ 89
/ 1998 / Interferon decreases hepatocellular carcinogenesis in pa-tients with cirrhosis caused by the hepatitis B virus 82 : 827 ~ 835
/ 1999 / Polymorphism in RANTES chemokine promoter affects HIV-1 di
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