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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 29 - 34 (6page)
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Background and Objectives: The relationship between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) is still controversial. Some studies suggested that molecular basis of the association between HT and PTC. BRAFV600E mutation is the most common genetic alteration founded in PTC. This study was to determine a role of BRAFV600E mutation in PTC with concurrent HT and their association with other clinicopathological factors. Materials and Methods: We enrolled 452 patients who underwent thyroid surgery between 2009 and 2012 for classical PTC. The status of BRAFV600E mutation was evaluated by direct sequencing. HT was defined as presence of lymphocytic thyroiditis in pathology or positive serum anti-thyroid peroxidase antibody. Results: Total 139 patients (30%) with PTC had coexistence HT. HT was significantly associated female (p=0.006), and younger age (p=0.045). BRAFV600E mutation was confirmed in 264 patients (58%). The frequency of BRAFV600E mutation was significantly lower in PTC with coexistence HT (48.2%) compared by PTC without HT (62.9%, p=0.004). However, there was no significant difference in clinicopathological feature of PTC according to the presence of HT in patients with BRAFV600E mutated PTC. BRAFV600E mutation was less frequent in PTC with coexistence HT. Conclusion: These findings suggested that HT and BRAFV600E mutation might be independent factors in development and progression of PTC.
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참고문헌 (30)
참고문헌 신청
Kilfoy BA / 2009 / International patterns and trends in thyroid cancer incidence, 1973-2002 / Cancer Causes Control 20(5):525~531
안화영 / 2009 / 우리나라 갑상선암의 발생 현황 및 특징 / 대한내과학회지 77(5):537~542
DeGroot LJ / 1990 / Natural history, treatment, and course of papillary thyroid carcinoma / J Clin Endocrinol Metab 71(2):414~424
Staii A / 2010 / Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state / Thyroid Res 3(1):11
Jankovic B / 2013 / Clinical review: Hashimoto's thyroiditis and papillary thyroid carcinoma: is there a correlation / J Clin Endocrinol Metab 98(2):474~482
안화영 / 2009 / 우리나라 갑상선암의 발생 현황 및 특징 / 대한내과학회지 77(5):537~542
DeGroot LJ / 1990 / Natural history, treatment, and course of papillary thyroid carcinoma / J Clin Endocrinol Metab 71(2):414~424
Staii A / 2010 / Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state / Thyroid Res 3(1):11
Jankovic B / 2013 / Clinical review: Hashimoto's thyroiditis and papillary thyroid carcinoma: is there a correlation / J Clin Endocrinol Metab 98(2):474~482
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