BRAFV600E Test for Suspicious Lateral Lymph Nodes in Papillary Thyroid Cancer

김완욱; Hyang Hee Choi; 이지연; Seung Ook Hwang; Ho Yong Park; Ji-Young Park; 정진향

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자료유형: 학술저널

저자정보: 김완욱 Hyang Hee Choi 이지연 Seung Ook Hwang Ho Yong Park Ji-Young Park 정진향

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제16권 제2호

발행연도: 2016.1

수록면: 36 - 41 (6page)

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Purpose: This study evaluates the BRAFV600E test with fine-needle aspiration cytology (FNAC) for lateral lymph node (LN) metastasis in papillary thyroid carcinoma (PTC).Methods: Ninety-one patients, including 95 lateral LNs with possible PTC metastasis, were consecutively entered into the study. We analyzed the accuracy of results for the BRAFV600Etest and FNAC for lateral LN metastasis in PTC. Results: Modified radical neck dissection was performed for 34 cases due to lateral LN metastasis. The sensitivity of FNAC was 88.2% , and the LN-BRAFV600E test 64.7%. The specificity and positive predictive value (PPV) were 100% for both tests. The negative predictive values (NPV) were FNAC, 93.8%, and LN-BRAFV600E, 83.6%. For samples positive with either the BRAFV600E test or FNAC, the sensitivity was 94.1%, specificity 100%, PPV value 100%, and NPV 96.8%.Conclusion: This study suggests that the complementary LN-BRAFV600E test with FNAC is a supportive diagnostic method for PTC patients with indeterminate or non-diagnostic suspicious lateral LNs.

#BRAFV600E mutation #Lymph node #Metastasis #Papillary thyroid cancer

참고문헌 (13)

참고문헌 신청

Zuniga S / 2009 / Prophylactic central neck dissection in stage N0 papillary thyroid carcinoma / Arch Otolaryngol Head Neck Surg 135:1087~1091

Kim KW / 2010 / Clinical characteristics of papillary thyroid microcarcinoma / J Korean Thyroid Assoc 3:111~115

Mazzaferri EL / 1994 / Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer / Am J Med 97:418~428

Schlumberger MJ / 1998 / Papillary and follicular thyroid carcinoma / N Engl J Med 338:297~306

Kim MJ / 2009 / Thyroglobulin measurement in fine-needle aspirate washouts:the criteria for neck node dissection for patients with thyroid cancer / Clin Endocrinol (Oxf) 70:145~151

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