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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 152 - 159 (8page)
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Background and Objectives: Sodium-iodine symporter (NIS) is a marker for the degree of differentiation in thyroid cancer. The genetic factors or microenvironment surrounding tumors can affect transcription of NIS. In this study, we investigated the NIS mRNA expression according to mutational status and coexistent lymphocytic thyroiditis in papillary thyroid cancer (PTC). Materials and Methods: The RNA expression levels of NIS in the samples from database of The Caner Genome Atlas (TCGA; n=494) and our institute (n=125) were analyzed. Results: The PTCs with the BRAFV600E mutation and the coexistence of BRAFV600E and TERT promoter mutations showed significantly lower expression of NIS (p＜0.001, respectively), and those with BRAF-like molecular subtype also had reduced expression of NIS (p＜0.001). NIS expression showed a positive correlation with thyroid differentiation score (r=0.593, p＜0.001) and negative correlations with expressions of genes involved in ERK signaling (r=−0.164, p＜0.001) and GLUT-1 gene (r=−0.204, p＜0.001). The PTCs with lymphocytic thyroiditis showed significantly higher NIS expression (p=0.013), regardless of mutational status. Conclusion: The NIS expression was reduced by the BRAFV600E mutation and MAPK/ERK pathway activation, but restored by the presence of lymphocytic thyroiditis.
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참고문헌 (23)
참고문헌 신청
Schlumberger M / 2007 / Defects in iodide metabolism in thyroid cancer and implications for the follow-up and treatment of patients / Nat Clin Pract Endocrinol Metab 3(3):260~269
Spitzweg C / 2014 / Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets / Lancet Diabetes Endocrinol 2(10):830~842
Cancer Genome Atlas Research Network / 2014 / Integrated genomic characterization of papillary thyroid carcinoma / Cell 159(3):676~690
Yoo SK / 2016 / Comprehensive analysis of the transcriptional and mutational landscape of follicular and papillary thyroid cancers / PLoS Genet 12(8):e1006239
Song YS / 2016 / Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients / Cancer 122(9):1370~1379
Spitzweg C / 2014 / Advanced radioiodine-refractory differentiated thyroid cancer: the sodium iodide symporter and other emerging therapeutic targets / Lancet Diabetes Endocrinol 2(10):830~842
Cancer Genome Atlas Research Network / 2014 / Integrated genomic characterization of papillary thyroid carcinoma / Cell 159(3):676~690
Yoo SK / 2016 / Comprehensive analysis of the transcriptional and mutational landscape of follicular and papillary thyroid cancers / PLoS Genet 12(8):e1006239
Song YS / 2016 / Prognostic effects of TERT promoter mutations are enhanced by coexistence with BRAF or RAS mutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients / Cancer 122(9):1370~1379
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