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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,392 - 1,399 (8page)
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초록· 키워드
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Purpose The association between tobacco smoking and thyroid cancer remains uncertain. We evaluated the associations of active and passive smoking with the risk of papillary thyroid cancer (PTC), the most common type of thyroid cancer, and with the BRAFV600Emutation, the most common oncogenic mutation in PTC related to poor prognosis. Materials and Methods We conducted this study with newly diagnosed PTC patients (n=2,142) and community controls (n=21,420) individually matched to cases for age and sex. Information on active and passive smoking and potential confounders were obtained from structured questionnaires, anthropometric measurements, and medical records. BRAFV600Emutation status was assessed in PTC patients. We evaluated the associations of active and passive smoking with PTC and BRAFV600E mutation risk using conditional and unconditional logistic regression models, respectively. Results We did not find associations between exposure indices of active and passive smoking and PTC risk in both men and women, except for the association between current smoking and lower PTC risk. Cumulative smoking 20 pack-years was associated with lower BRAFV600E mutation risk in male PTC patients (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.30 to 1.00). The CI for the association was wider in female PTC patients (OR, 0.23; 95% CI, 0.02 to 2.62), possibly owing to a smaller sample size in this stratum. Conclusion We did not find consistent associations between active and passive smoking and PTC risk. Cumulative smoking 20 pack-years was associated with lower BRAFV600Emutation risk in male PTC patients.
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참고문헌 (31)
참고문헌 신청
Pellegriti G / 2013 / Worldwide increasing incidence of thyroid cancer : update on epidemiology and risk factors / J Cancer Epidemiol 2013:965212
정규원 / 2018 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 / Cancer Research and Treatment 50(2):303~316
Li N / 2013 / Impact of enhanced detection on the increase in thyroid cancer incidence in the United States : review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980-2008 / Thyroid 23:103~110
Cramer JD / 2010 / Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry / Surgery 148:1147~1152
Vigneri R / 2015 / The changing epidemiol-ogy of thyroid cancer: why is incidence increasing? / Curr Opin Oncol 27:1~7
정규원 / 2018 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 / Cancer Research and Treatment 50(2):303~316
Li N / 2013 / Impact of enhanced detection on the increase in thyroid cancer incidence in the United States : review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980-2008 / Thyroid 23:103~110
Cramer JD / 2010 / Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry / Surgery 148:1147~1152
Vigneri R / 2015 / The changing epidemiol-ogy of thyroid cancer: why is incidence increasing? / Curr Opin Oncol 27:1~7
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