지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 238 - 238 (1page)
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초록· 키워드
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Purpose
The BRAF V600E mutation is an independent, it is associated with high-risk prognostic factors in Classical papillary thyroid carcinoma (C-PTC). However, some C-PTC BRAF wild-type also have poor prognosis. Our aim is to find out genetic alternation in the C-PTC BRAFV600E and C-PTC BRAF wild-type.
Methods
The clinicopathological characteristics, gene mutation types, and mRNA expression profiles of patients with CPTC were studied utilizing the data downloaded from GEO database. Differentially expressed genes (DEGs) were identified, and functional enrichment analysis was applied. A protein-protein interaction (PPI) network was constructed to identify hub genes and the predictive accuracy of hub genes were evaluated using the receiver operating characteristic (ROC) curve.
Results
A total of 198 and 300 DEGs were screened out from C-PTC BRAFV600E and C-PTC BRAF wild-type, respectively. The top 5 hub genes in the constructed PPI network were FN1, ICAM1, CCND1, APOE, CD44 for CPTC BRAFV600E. And for C-PTC BRAF wild-type were SPP1, CXCL8, TIMP1, APOE, FN1 respectively with ... 전체 초록 보기
The BRAF V600E mutation is an independent, it is associated with high-risk prognostic factors in Classical papillary thyroid carcinoma (C-PTC). However, some C-PTC BRAF wild-type also have poor prognosis. Our aim is to find out genetic alternation in the C-PTC BRAFV600E and C-PTC BRAF wild-type.
Methods
The clinicopathological characteristics, gene mutation types, and mRNA expression profiles of patients with CPTC were studied utilizing the data downloaded from GEO database. Differentially expressed genes (DEGs) were identified, and functional enrichment analysis was applied. A protein-protein interaction (PPI) network was constructed to identify hub genes and the predictive accuracy of hub genes were evaluated using the receiver operating characteristic (ROC) curve.
Results
A total of 198 and 300 DEGs were screened out from C-PTC BRAFV600E and C-PTC BRAF wild-type, respectively. The top 5 hub genes in the constructed PPI network were FN1, ICAM1, CCND1, APOE, CD44 for CPTC BRAFV600E. And for C-PTC BRAF wild-type were SPP1, CXCL8, TIMP1, APOE, FN1 respectively with ... 전체 초록 보기
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하시모토 갑상선염을 동반한 갑상선유두암에서 BRAFV600E 돌연변이의 임상병리학적 의미
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