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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 600 - 604 (5page)
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초록· 키워드
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Background and Objectives This study aimed to identify a reliable preoperative predictivefactor for the development of thyroid cancer in patients with atypia of undetermined significance(AUS) identified by fine needle aspiration biopsy (FNAB). Subjects and Method This was a retrospective cohort study. Two hundred and ninety-ninepatients diagnosed with AUS by preoperative FNAB who underwent curative thyroid surgeryat our institution between September 2005 and February 2014 were analyzed. Clinical, radiologicaland molecular features were investigated as preoperative predictors for postoperativepermanent malignant pathology. Results The final pathologic results revealed 36 benign tumors including nodular hyperplasia,follicular adenoma, adenomatous goiter, nontoxic goiter, and lymphocytic thyroiditis, aswell as 263 malignant tumors including 1 follicular carcinoma and 1 invasive follicular carcinoma;the rest were papillary thyroid carcinomas. The malignancy rate was 87.9%. The followingwere identified as risk factors for malignancy by univariate analysis: BRAFV600E genemutation, specific ultrasonographic findings including smaller nodule size, low echogenicityof the nodule, and irregular or spiculated margin (p＜0.05). Multivariate analysis revealed thatonly BRAFV600E mutation was a statistically significant risk factor for malignancy (p＜0.05). When BRAFV600E mutation was positive, 98.5% of enrolled patients developed malignant tumors. In addition, the diagnostic rate of malignancy in these cases was approximately 16-foldhigher than BRAF-negative cases. Conclusion Patients with AUS thyroid nodules should undergo BRAFV600E gene mutationanalysis to improve diagnostic accuracy and if the mutation is confirmed, surgery is recommendeddue to the high risk of malignancy.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Özemir İA / 2016 / The association of papillary thyroid cancer with microcalcification in thyroid nodules with indeterminate cytology based on fine-needle aspiration biopsy / Turk J Med Sci 46(6):1719~1723
Turkyilmaz S / 2017 / Thyroid nodules classified as atypia or follicular lesions of undetermined significance deserve further research: analysis of 305 surgically confirmed nodules / Cytopathology 28(5):391~399
Russ G / 2014 / Thyroid incidentalomas: epidemiology, risk stratification with ultrasound and workup / Eur Thyroid J 3(3):154~163
Estrada Muñoz L / 2017 / Thyroid atypia/follicular lesion of undetermined significance: attitudes towards the diagnosis of Bethesda system III nodules / Acta Cytol 61(1):21~26
Gao LY / 2017 / Ultrasound is helpful to differentiate Bethesdaclass III thyroid nodules a PRISMA-compliant systematic review and meta-analysis / Medicine 96(16):e6564
Turkyilmaz S / 2017 / Thyroid nodules classified as atypia or follicular lesions of undetermined significance deserve further research: analysis of 305 surgically confirmed nodules / Cytopathology 28(5):391~399
Russ G / 2014 / Thyroid incidentalomas: epidemiology, risk stratification with ultrasound and workup / Eur Thyroid J 3(3):154~163
Estrada Muñoz L / 2017 / Thyroid atypia/follicular lesion of undetermined significance: attitudes towards the diagnosis of Bethesda system III nodules / Acta Cytol 61(1):21~26
Gao LY / 2017 / Ultrasound is helpful to differentiate Bethesdaclass III thyroid nodules a PRISMA-compliant systematic review and meta-analysis / Medicine 96(16):e6564
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